Mechanism of Action - Pharmacy Freak

Mechanism of Action of Amivantamab

July 16, 2026 Harsh Singh Rajput

Introduction Amivantamab is a targeted anticancer monoclonal antibody used in selected patients with non-small cell lung cancer, commonly abbreviated as NSCLC. It is marketed under the brand name Rybrevant as intravenous amivantamab-vmjw. A subcutaneous formulation, Rybrevant Faspro, contains amivantamab with hyaluronidase-lpuj, but the key anticancer antibody component is amivantamab. Pharmacologically, amivantamab is a bispecific antibody … Read more

Mechanism of Action of Secukinumab

July 16, 2026 Harsh Singh Rajput

Introduction Secukinumab is a biologic immunomodulator marketed under the brand name Cosentyx. Pharmacologically, it is a human interleukin-17A antagonist and a recombinant human IgG1 kappa monoclonal antibody. Interleukin-17A, commonly called IL-17A, is a pro-inflammatory cytokine involved in immune defense and chronic inflammatory disease. It is produced mainly by Th17 cells, but other immune cells such … Read more

Mechanism of Action of Trametinib

July 15, 2026 Harsh Singh Rajput

Introduction Trametinib is an oral targeted anticancer drug marketed under the brand name Mekinist. Pharmacologically, trametinib belongs to the mitogen-activated extracellular signal-regulated kinase inhibitor class, commonly called MEK inhibitors. MEK1 and MEK2 are important kinases in the RAS-RAF-MEK-ERK signaling pathway. This pathway regulates cell growth, proliferation, survival, differentiation, and migration. In several cancers, mutations in … Read more

Mechanism of Action of Guselkumab

July 14, 2026 Harsh Singh Rajput

Introduction Guselkumab is a biologic immunomodulator used in inflammatory immune-mediated diseases. It is marketed under the brand name Tremfya. Pharmacologically, guselkumab is an interleukin-23 antagonist and a human IgG1 lambda monoclonal antibody. Interleukin-23, commonly called IL-23, is an important cytokine involved in chronic inflammation. It plays a major role in the activation and maintenance of … Read more

Mechanism of Action of Verzenio

July 13, 2026 Harsh Singh Rajput

Introduction Verzenio is the brand name of abemaciclib, an oral targeted anticancer drug used in selected patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancer. Pharmacologically, Verzenio belongs to the cyclin-dependent kinase 4 and 6 inhibitor class, commonly called CDK4/6 inhibitors. CDK4 and CDK6 are key enzymes that regulate progression of cells … Read more

Mechanism of Action of Kesimpta

July 13, 2026 Harsh Singh Rajput

Introduction Kesimpta is the brand name of ofatumumab, a subcutaneous monoclonal antibody used for relapsing forms of multiple sclerosis. Pharmacologically, Kesimpta is a CD20-directed cytolytic antibody. It is used in adults with relapsing forms of multiple sclerosis, including clinically isolated syndrome, relapsing-remitting multiple sclerosis, and active secondary progressive multiple sclerosis. Multiple sclerosis is an immune-mediated … Read more

Mechanism of Action of Latuda

July 12, 2026 Harsh Singh Rajput

Introduction Latuda is the brand name of lurasidone hydrochloride, an oral atypical antipsychotic drug. It is mainly used for schizophrenia and depressive episodes associated with bipolar I disorder. Pharmacologically, lurasidone is classified as a second-generation antipsychotic, also called an atypical antipsychotic. Lurasidone works by modulating dopamine and serotonin neurotransmission in the brain. The exact therapeutic … Read more

Mechanism of Action of Tafamidis

July 12, 2026 Harsh Singh Rajput

Introduction Tafamidis is an oral disease-modifying drug used for transthyretin amyloid cardiomyopathy, commonly abbreviated as ATTR-CM. It is marketed under the brand names Vyndaqel and Vyndamax. Pharmacologically, tafamidis is a transthyretin stabilizer. Transthyretin, or TTR, is a transport protein mainly produced by the liver. It normally circulates as a tetramer, meaning it is made of … Read more

Mechanism of Action of Ponatinib

July 12, 2026 Harsh Singh Rajput

Introduction Ponatinib is an oral targeted anticancer drug used in selected Philadelphia chromosome-positive leukemias. It is marketed under the brand name Iclusig. Pharmacologically, ponatinib belongs to the BCR-ABL tyrosine kinase inhibitor class and is often described as a third-generation BCR-ABL inhibitor. Philadelphia chromosome-positive chronic myeloid leukemia, or Ph+ CML, and Philadelphia chromosome-positive acute lymphoblastic leukemia, … Read more

Mechanism of Action of Pegcetacoplan

July 12, 2026 Harsh Singh Rajput

Introduction Pegcetacoplan is a targeted complement inhibitor used in diseases driven by abnormal activation of the complement system. It is marketed as Empaveli for systemic use and as Syfovre for intravitreal ophthalmic use. Empaveli is used for adult patients with paroxysmal nocturnal hemoglobinuria, commonly called PNH, and is also indicated for adults and pediatric patients … Read more