Rheumatoid Arthritis - Pharmacy Freak

Mechanism of Action of Infliximab (Remicade)

April 10, 2026July 6, 2025 Pharmacy Freak Editorial Team Harsh Singh Rajput

Introduction Infliximab is a chimeric (murine-human) IgG1 monoclonal antibody that targets tumor necrosis factor‑α (TNF‑α). It is used to treat a range of autoimmune and inflammatory disorders, including rheumatoid arthritis (RA), psoriatic arthritis (PsA), ankylosing spondylitis (AS), Crohn’s disease, ulcerative colitis, and plaque psoriasis. Step-by-Step Mechanism of Action Pharmacokinetic Parameters Parameter Value Route Intravenous infusion … Read more

Mechanism of Action of Adalimumab (Humira)

April 10, 2026July 4, 2025 Pharmacy Freak Editorial Team Harsh Singh Rajput

Introduction Adalimumab is a fully human monoclonal IgG1 antibody that specifically targets tumor necrosis factor‑α (TNF‑α). By neutralizing TNF‑α, it reduces inflammation across a variety of autoimmune conditions, including rheumatoid arthritis (RA), psoriatic arthritis (PsA), ankylosing spondylitis (AS), Crohn’s disease, ulcerative colitis, and plaque psoriasis. Step-by-Step Mechanism of Action Pharmacokinetic Parameters Parameter Value Route Subcutaneous … Read more

Mechanism of Action of Etanercept (Enbrel)

April 10, 2026July 4, 2025 Pharmacy Freak Editorial Team Harsh Singh Rajput

Introduction Etanercept is a biologic fusion protein that functions as a soluble tumor necrosis factor (TNF) receptor. By binding TNF-α and TNF-β in circulation, it blocks their interaction with cell surface receptors, reducing systemic inflammation. It is approved for rheumatoid arthritis (RA), psoriatic arthritis (PsA), ankylosing spondylitis (AS), juvenile idiopathic arthritis (JIA), and plaque psoriasis. … Read more

Mechanism of Action of Tocilizumab

April 10, 2026July 3, 2025 Pharmacy Freak Editorial Team Harsh Singh Rajput

Introduction Tocilizumab is a humanized monoclonal antibody targeting the interleukin-6 receptor (IL-6R). It is approved for rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), giant cell arteritis (GCA), Castleman disease, cytokine release syndrome (CRS), and spondyloarthritis-associated uveitis. By blocking IL-6 signaling, it dampens inflammation in various autoimmune and inflammatory diseases. Step-by-Step Mechanism of Action Pharmacokinetic Parameters … Read more

Mechanism of Action of Anakinra

April 10, 2026July 2, 2025 Pharmacy Freak Editorial Team Harsh Singh Rajput

Introduction Anakinra is a recombinant human interleukin‑1 receptor antagonist (IL‑1Ra) used to treat rheumatoid arthritis, neonatal-onset multisystem inflammatory disease (NOMID), and other autoinflammatory conditions. It competitively inhibits IL‑1α and IL‑1β binding to IL‑1 receptors, effectively reducing inflammation. Step-by-Step Mechanism of Action Pharmacokinetic Parameters Parameter Value Route Subcutaneous injection (daily) Bioavailability ~95% Time to Peak (Tmax) … Read more