Introduction Trulicity is the brand name of dulaglutide, a once-weekly injectable antidiabetic medicine used in type 2 diabetes mellitus. Pharmacologically, dulaglutide is a glucagon-like peptide-1 receptor agonist, commonly called a GLP-1 receptor agonist. GLP-1 is an incretin hormone released from intestinal L-cells after food intake. It helps regulate blood glucose by increasing insulin secretion, decreasing … Read more
Introduction Glucagon-like peptide-1 (GLP-1) is an endogenous incretin hormone secreted from the L-cells of the distal ileum and colon in response to food intake. It plays a critical role in regulating glucose homeostasis and energy balance. GLP-1 acts through specific receptors found in the pancreas, gastrointestinal tract, and central nervous system to modulate insulin secretion, … Read more
Introduction Semaglutide (Ozempic for diabetes; Wegovy for obesity) is a GLP‑1 receptor agonist used for type 2 diabetes mellitus management and chronic weight loss. It mimics the incretin hormone glucagon‑like peptide‑1 (GLP‑1), leading to improved glycemic control, reduced appetite, delayed gastric emptying, and favorable effects on cardiovascular risk. Step-by-Step Mechanism of Action Pharmacokinetic Parameters Parameter Value … Read more
