Introduction Romosozumab is a humanized monoclonal antibody used for the treatment of osteoporosis in postmenopausal women who are at high risk of fracture. It is marketed under the brand name Evenity. Pharmacologically, romosozumab belongs to the sclerostin inhibitor class and is considered an anabolic bone-forming therapy with an additional antiresorptive effect. Osteoporosis is characterized by … Read more
Introduction Valbenazine is an oral drug used for the treatment of abnormal involuntary movements. It is marketed under the brand names Ingrezza and Ingrezza Sprinkle. Pharmacologically, valbenazine is a vesicular monoamine transporter 2 inhibitor, commonly abbreviated as a VMAT2 inhibitor. Valbenazine is mainly used in adults with tardive dyskinesia and chorea associated with Huntington’s disease. … Read more
Introduction Olaparib is an oral anticancer drug that belongs to the poly ADP-ribose polymerase inhibitor class, commonly called PARP inhibitors. It is marketed under the brand name Lynparza. Olaparib is an important targeted anticancer drug used in cancers with defects in DNA repair pathways, especially BRCA1, BRCA2, and other homologous recombination repair gene abnormalities. The … Read more
Introduction Cladribine is a purine nucleoside analogue used as an immunosuppressive and antineoplastic drug. It is available under important brand names such as Mavenclad for relapsing forms of multiple sclerosis and Leustatin for hairy cell leukemia. Pharmacologically, cladribine is an adenosine analogue that is resistant to degradation by adenosine deaminase, allowing it to persist inside … Read more
Introduction Brilinta is the brand name of ticagrelor, an oral antiplatelet drug used mainly to prevent thrombotic cardiovascular and cerebrovascular events. It belongs to the P2Y12 platelet receptor inhibitor class and is commonly used in patients with acute coronary syndrome, history of myocardial infarction, coronary artery disease at high risk of thrombotic events, and selected … Read more
Introduction Eltrombopag is an oral thrombopoietin receptor agonist used to increase platelet production in selected patients with thrombocytopenia. It is marketed under the brand name Promacta in the United States and Revolade in some other countries. Pharmacologically, eltrombopag is classified as a non-peptide thrombopoietin receptor agonist. Thrombopoietin, also called TPO, is the natural hormone that … Read more
Introduction Lurbinectedin is an intravenous anticancer drug marketed under the brand name Zepzelca. It belongs to the class of alkylating antineoplastic agents and is mainly used in small cell lung cancer, a highly aggressive neuroendocrine lung cancer that often responds initially to platinum-based chemotherapy but commonly relapses. Lurbinectedin is pharmacologically important because it targets DNA … Read more
Introduction Ibrance is the brand name of palbociclib, an oral targeted anticancer drug belonging to the class of cyclin-dependent kinase 4 and 6 inhibitors, commonly called CDK4/6 inhibitors. It is mainly used in hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced or metastatic breast cancer. Ibrance is pharmacologically important because it targets a key … Read more
Introduction Mavacamten is an oral cardiac myosin inhibitor marketed under the brand name Camzyos. It is used for the treatment of adults with symptomatic New York Heart Association class II–III obstructive hypertrophic cardiomyopathy, also called obstructive HCM or oHCM, to improve functional capacity and symptoms. Current prescribing information describes Camzyos as a cardiac myosin inhibitor … Read more
Introduction Canakinumab is a recombinant human monoclonal antibody used as a targeted anti-inflammatory biologic. It is marketed under the brand name Ilaris and belongs to the class of interleukin-1 beta inhibitors. Canakinumab specifically blocks interleukin-1 beta, also written as IL-1β, a powerful pro-inflammatory cytokine involved in fever, neutrophil recruitment, acute-phase response, joint inflammation, systemic inflammation, … Read more
