Major Depressive Disorder - Pharmacy Freak

Mechanism of Action of Vilazodone

August 10, 2026 Harsh Singh Rajput

Introduction Vilazodone is an oral antidepressant marketed under the brand name Viibryd. Pharmacologically, vilazodone is commonly described as a serotonin reuptake inhibitor and serotonin 5-HT1A receptor partial agonist. Major depressive disorder, commonly called MDD, is a psychiatric disorder involving persistent low mood, anhedonia, sleep disturbance, appetite changes, fatigue, guilt, impaired concentration, psychomotor changes, and suicidal … Read more

Mechanism of Action of Cariprazine

August 12, 2026August 8, 2026 Harsh Singh Rajput

Introduction Cariprazine is an oral atypical antipsychotic marketed under the brand name Vraylar. Pharmacologically, cariprazine is a dopamine-serotonin receptor modulator with partial agonist activity at dopamine D3 and D2 receptors and serotonin 5-HT1A receptors, plus antagonist activity at serotonin 5-HT2A receptors. Psychiatric disorders such as schizophrenia, bipolar I disorder, and major depressive disorder involve complex … Read more

Mechanism of Action of Spravato

August 5, 2026 Harsh Singh Rajput

Introduction Spravato is the brand name of esketamine, a nasal spray antidepressant used in selected adults with major depressive disorder. Pharmacologically, esketamine is a non-selective, non-competitive N-methyl-D-aspartate receptor antagonist, commonly called an NMDA receptor antagonist. Depression is a complex psychiatric disorder involving mood, cognition, sleep, appetite, motivation, reward processing, stress regulation, neuroplasticity, and multiple neurotransmitter … Read more

Mechanism of Action of Lumateperone

July 21, 2026 Harsh Singh Rajput

Introduction Lumateperone is an oral atypical antipsychotic marketed under the brand name Caplyta. It is used in adults for schizophrenia, depressive episodes associated with bipolar I or bipolar II disorder, and as adjunctive therapy with antidepressants for major depressive disorder. The current U.S. prescribing information lists the recommended Caplyta dose as 42 mg orally once … Read more

Mechanism of Action of Rexulti

July 20, 2026 Harsh Singh Rajput

Introduction Rexulti is the brand name of brexpiprazole, an oral atypical antipsychotic used in psychiatric and neuropsychiatric conditions. Pharmacologically, brexpiprazole is a serotonin-dopamine activity modulator with partial agonist activity at dopamine D2 and serotonin 5-HT1A receptors, along with antagonist activity at serotonin 5-HT2A receptors. Rexulti is used as adjunctive therapy with antidepressants for major depressive … Read more

Mechanism of Action of Vraylar

June 28, 2026 Harsh Singh Rajput

Introduction Vraylar is the brand name of cariprazine, an oral atypical antipsychotic used in schizophrenia, bipolar I disorder, and major depressive disorder as adjunctive therapy. Current prescribing information lists Vraylar for schizophrenia in adults and pediatric patients 13 years and older, acute manic or mixed episodes associated with bipolar I disorder in adults and pediatric … Read more

Mechanism of Action of Trintellix

June 27, 2026 Harsh Singh Rajput

Introduction Trintellix is the brand name of vortioxetine, an oral antidepressant used for the treatment of major depressive disorder in adults. It is commonly described as a multimodal serotonergic antidepressant because it affects serotonin reuptake and multiple serotonin receptor subtypes. Current prescribing information lists Trintellix as indicated for major depressive disorder in adults. Trintellix is … Read more

Mechanism of Action of Caplyta

June 27, 2026 Harsh Singh Rajput

Introduction Caplyta is the brand name of lumateperone, an oral atypical antipsychotic used in adults for schizophrenia, depressive episodes associated with bipolar I or bipolar II disorder, and as adjunctive treatment with an antidepressant for major depressive disorder. It is not known whether Caplyta is safe and effective in children. Caplyta is important in pharmacology … Read more

Mechanism of Action of Auvelity

June 22, 2026 Harsh Singh Rajput

Introduction Auvelity is a fixed-dose oral combination of dextromethorphan hydrobromide and bupropion hydrochloride. It is used for the treatment of major depressive disorder in adults, and its U.S. use has also expanded to agitation associated with dementia due to Alzheimer’s disease in adults. Auvelity is pharmacologically important because it combines two drugs with different but … Read more