Introduction Cariprazine is an oral atypical antipsychotic marketed under the brand name Vraylar. Pharmacologically, cariprazine is a dopamine-serotonin receptor modulator with partial agonist activity at dopamine D3 and D2 receptors and serotonin 5-HT1A receptors, plus antagonist activity at serotonin 5-HT2A receptors. Psychiatric disorders such as schizophrenia, bipolar I disorder, and major depressive disorder involve complex … Read more
Introduction Teclistamab is an anticancer immunotherapy marketed under the brand name Tecvayli. Pharmacologically, teclistamab-cqyv is a bispecific B-cell maturation antigen-directed CD3 T-cell engager used in relapsed or refractory multiple myeloma. Multiple myeloma is a malignant plasma-cell disorder. In this disease, abnormal plasma cells accumulate in the bone marrow and produce monoclonal immunoglobulin or light chains. … Read more
Introduction Xcopri is the brand name of cenobamate, an oral antiseizure medication used for the treatment of partial-onset seizures in adults. Pharmacologically, cenobamate is an antiseizure drug with dual actions on neuronal excitability: inhibition of voltage-gated sodium currents and positive allosteric modulation of GABA-A ion channels. Partial-onset seizures, also called focal seizures, begin in one … Read more
Introduction Tenapanor is an oral, locally acting gastrointestinal drug marketed under two important brand names: Ibsrela and Xphozah. Pharmacologically, tenapanor is a sodium/hydrogen exchanger 3 inhibitor, commonly written as an NHE3 inhibitor. NHE3 is an antiporter located on the apical surface of intestinal epithelial cells in the small intestine and colon. It plays an important … Read more
Introduction Patiromer is an oral potassium-binding drug marketed under the brand name Veltassa. Pharmacologically, patiromer is a non-absorbed cation exchange polymer used for the treatment of hyperkalemia. Hyperkalemia means increased serum potassium concentration. Potassium is essential for normal nerve conduction, skeletal muscle contraction, and cardiac electrical activity. However, excessive potassium can disturb cardiac conduction and … Read more
Introduction Rybrevant is the brand name of amivantamab-vmjw, an anticancer biologic used in selected patients with non-small cell lung cancer, commonly abbreviated as NSCLC. Pharmacologically, Rybrevant is a bispecific antibody directed against two important receptor targets: epidermal growth factor receptor, or EGFR, and MET receptor. NSCLC is a major type of lung cancer. In some … Read more
Introduction Dabrafenib is an oral targeted anticancer drug marketed under the brand name Tafinlar. Pharmacologically, dabrafenib is a BRAF kinase inhibitor used in selected cancers with activating BRAF mutations. The BRAF protein is a serine/threonine kinase in the RAS-RAF-MEK-ERK signaling pathway, also called the MAPK pathway. This pathway normally transmits growth signals from cell-surface receptors … Read more
Introduction Suvorexant is an oral hypnotic drug marketed under the brand name Belsomra. Pharmacologically, suvorexant is a dual orexin receptor antagonist, commonly called a DORA. Insomnia is a sleep disorder characterized by difficulty falling asleep, difficulty staying asleep, or both. Unlike traditional sedative-hypnotic drugs that broadly depress the central nervous system through GABAergic mechanisms, suvorexant … Read more
Introduction Camzyos is the brand name of mavacamten, an oral cardiac myosin inhibitor used in obstructive hypertrophic cardiomyopathy, commonly called obstructive HCM or oHCM. Hypertrophic cardiomyopathy is a disease in which the heart muscle, especially the left ventricle, becomes abnormally thickened. In obstructive HCM, the thickened septum and abnormal ventricular contraction can narrow the left … Read more
Introduction Asciminib is an oral targeted anticancer drug marketed under the brand name Scemblix. Pharmacologically, asciminib is an ABL/BCR-ABL1 tyrosine kinase inhibitor used in Philadelphia chromosome-positive chronic myeloid leukemia, commonly abbreviated as Ph+ CML. Chronic myeloid leukemia is driven by the Philadelphia chromosome, which forms due to a translocation between chromosomes 9 and 22. This … Read more
