Introduction Dasatinib is an oral targeted anticancer drug belonging to the class of tyrosine kinase inhibitors. It is best known by the brand name Sprycel and is mainly used in Philadelphia chromosome-positive leukemias, especially chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia. The Philadelphia chromosome results from a translocation between chromosomes 9 and 22, … Read more
Introduction Uplizna is the brand name of inebilizumab-cdon, a CD19-directed humanized monoclonal antibody used in selected autoimmune neurological and immune-mediated diseases. It belongs to the class of B-cell-depleting biologic therapies. Uplizna is indicated in adults for anti-aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder, immunoglobulin G4-related disease, and generalized myasthenia gravis in patients who are anti-acetylcholine receptor … Read more
Introduction Belimumab is a human IgG1λ monoclonal antibody used in the treatment of autoimmune lupus disorders. It is marketed under the brand name Benlysta and is classified as a B-lymphocyte stimulator-specific inhibitor, also called a BLyS inhibitor or BAFF inhibitor. Belimumab is used in patients 5 years of age and older with active systemic lupus … Read more
Introduction Vraylar is the brand name of cariprazine, an oral atypical antipsychotic used in schizophrenia, bipolar I disorder, and major depressive disorder as adjunctive therapy. Current prescribing information lists Vraylar for schizophrenia in adults and pediatric patients 13 years and older, acute manic or mixed episodes associated with bipolar I disorder in adults and pediatric … Read more
Introduction Everolimus is an oral mammalian target of rapamycin inhibitor, commonly called an mTOR inhibitor. It is used as an anticancer drug, immunosuppressant, and targeted therapy in selected genetic and proliferative disorders. It is marketed under different brand names depending on indication, such as Afinitor for oncology and tuberous sclerosis complex-related conditions, and Zortress for … Read more
Introduction Ruxolitinib is an oral Janus kinase inhibitor used mainly in hematological and immune-mediated disorders. It is best known by the brand name Jakafi for systemic use, and it selectively inhibits Janus kinase 1 and Janus kinase 2, commonly called JAK1 and JAK2. Ruxolitinib is important in pharmacology because JAK enzymes are central mediators of … Read more
Introduction Kisqali is the brand name of ribociclib, an oral targeted anticancer drug used in hormone receptor-positive, HER2-negative breast cancer. It belongs to the class of cyclin-dependent kinase 4 and 6 inhibitors, commonly called CDK4/6 inhibitors. Kisqali is important in oncology pharmacology because it targets the cell cycle machinery that allows cancer cells to divide … Read more
Introduction Trintellix is the brand name of vortioxetine, an oral antidepressant used for the treatment of major depressive disorder in adults. It is commonly described as a multimodal serotonergic antidepressant because it affects serotonin reuptake and multiple serotonin receptor subtypes. Current prescribing information lists Trintellix as indicated for major depressive disorder in adults. Trintellix is … Read more
Introduction Caplyta is the brand name of lumateperone, an oral atypical antipsychotic used in adults for schizophrenia, depressive episodes associated with bipolar I or bipolar II disorder, and as adjunctive treatment with an antidepressant for major depressive disorder. It is not known whether Caplyta is safe and effective in children. Caplyta is important in pharmacology … Read more
Introduction Qelbree is the brand name of viloxazine extended-release, a non-stimulant drug used for the treatment of attention-deficit/hyperactivity disorder, commonly called ADHD. It is indicated for ADHD in adults and pediatric patients 6 years of age and older. Qelbree is pharmacologically important because it is different from stimulant ADHD medicines such as methylphenidate and amphetamine … Read more
