Introduction Lurbinectedin is an intravenous anticancer drug marketed under the brand name Zepzelca. It belongs to the class of alkylating antineoplastic agents and is mainly used in small cell lung cancer, a highly aggressive neuroendocrine lung cancer that often responds initially to platinum-based chemotherapy but commonly relapses. Lurbinectedin is pharmacologically important because it targets DNA … Read more
Introduction Ibrance is the brand name of palbociclib, an oral targeted anticancer drug belonging to the class of cyclin-dependent kinase 4 and 6 inhibitors, commonly called CDK4/6 inhibitors. It is mainly used in hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced or metastatic breast cancer. Ibrance is pharmacologically important because it targets a key … Read more
Introduction Dasatinib is an oral targeted anticancer drug belonging to the class of tyrosine kinase inhibitors. It is best known by the brand name Sprycel and is mainly used in Philadelphia chromosome-positive leukemias, especially chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia. The Philadelphia chromosome results from a translocation between chromosomes 9 and 22, … Read more
Introduction Everolimus is an oral mammalian target of rapamycin inhibitor, commonly called an mTOR inhibitor. It is used as an anticancer drug, immunosuppressant, and targeted therapy in selected genetic and proliferative disorders. It is marketed under different brand names depending on indication, such as Afinitor for oncology and tuberous sclerosis complex-related conditions, and Zortress for … Read more
Introduction Kisqali is the brand name of ribociclib, an oral targeted anticancer drug used in hormone receptor-positive, HER2-negative breast cancer. It belongs to the class of cyclin-dependent kinase 4 and 6 inhibitors, commonly called CDK4/6 inhibitors. Kisqali is important in oncology pharmacology because it targets the cell cycle machinery that allows cancer cells to divide … Read more
Introduction Alpelisib is an oral targeted anticancer drug that belongs to the class of phosphatidylinositol-3-kinase inhibitors. It is mainly known as a selective PI3K alpha inhibitor and is used in diseases driven by activating mutations in the PIK3CA gene. In oncology, alpelisib is used in combination with fulvestrant for patients with hormone receptor-positive, HER2-negative, PIK3CA-mutated … Read more
Introduction Trodelvy is the brand name for sacituzumab govitecan, an antibody-drug conjugate (ADC) used for the treatment of certain advanced or metastatic cancers, particularly triple-negative breast cancer (TNBC) and hormone receptor-positive/HER2-negative breast cancer after prior therapies. It combines the targeting capability of a monoclonal antibody with the potent cytotoxic activity of a chemotherapy payload. Sacituzumab … Read more
Introduction Bleomycin is a cytotoxic glycopeptide antibiotic used as an antineoplastic agent, especially in the treatment of Hodgkin lymphoma, testicular cancer, squamous cell carcinomas, and germ cell tumors. It is unique among chemotherapeutic agents because it causes minimal myelosuppression but is strongly associated with pulmonary toxicity. Bleomycin acts primarily during the G2 phase of the … Read more
