Mechanism of Action - Pharmacy Freak

Mechanism of Action of Patiromer

August 6, 2026 Harsh Singh Rajput

Introduction Patiromer is an oral potassium-binding drug marketed under the brand name Veltassa. Pharmacologically, patiromer is a non-absorbed cation exchange polymer used for the treatment of hyperkalemia. Hyperkalemia means increased serum potassium concentration. Potassium is essential for normal nerve conduction, skeletal muscle contraction, and cardiac electrical activity. However, excessive potassium can disturb cardiac conduction and … Read more

Mechanism of Action of Rybrevant

August 6, 2026 Harsh Singh Rajput

Introduction Rybrevant is the brand name of amivantamab-vmjw, an anticancer biologic used in selected patients with non-small cell lung cancer, commonly abbreviated as NSCLC. Pharmacologically, Rybrevant is a bispecific antibody directed against two important receptor targets: epidermal growth factor receptor, or EGFR, and MET receptor. NSCLC is a major type of lung cancer. In some … Read more

Mechanism of Action of Viloxazine

August 5, 2026 Harsh Singh Rajput

Introduction Viloxazine is an oral non-stimulant drug marketed under the brand name Qelbree. Pharmacologically, viloxazine is a selective norepinephrine reuptake inhibitor used in attention-deficit/hyperactivity disorder, commonly called ADHD. ADHD is a neurodevelopmental disorder characterized by persistent patterns of inattention, hyperactivity, impulsivity, or a combination of these symptoms. It can affect academic performance, work productivity, behavior, … Read more

Mechanism of Action of Spravato

August 5, 2026 Harsh Singh Rajput

Introduction Spravato is the brand name of esketamine, a nasal spray antidepressant used in selected adults with major depressive disorder. Pharmacologically, esketamine is a non-selective, non-competitive N-methyl-D-aspartate receptor antagonist, commonly called an NMDA receptor antagonist. Depression is a complex psychiatric disorder involving mood, cognition, sleep, appetite, motivation, reward processing, stress regulation, neuroplasticity, and multiple neurotransmitter … Read more

Mechanism of Action of Xeljanz

August 4, 2026August 4, 2026 Harsh Singh Rajput

Introduction Xeljanz is the brand name of tofacitinib, an oral immunomodulatory drug. Pharmacologically, tofacitinib is a Janus kinase inhibitor, commonly called a JAK inhibitor. Inflammatory autoimmune diseases such as rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, polyarticular course juvenile idiopathic arthritis, and ulcerative colitis are driven by abnormal immune-cell activation and cytokine signaling. Cytokines are chemical … Read more

Mechanism of Action of Deucravacitinib

August 4, 2026 Harsh Singh Rajput

Introduction Deucravacitinib is an oral immunomodulatory drug marketed under the brand name Sotyktu. Pharmacologically, deucravacitinib is a selective tyrosine kinase 2 inhibitor, commonly called a TYK2 inhibitor. Psoriasis and psoriatic arthritis are immune-mediated inflammatory diseases involving abnormal cytokine signaling, T-cell activation, keratinocyte inflammation, synovial inflammation, enthesitis, and systemic immune dysregulation. Important inflammatory pathways include interleukin-23, … Read more

Mechanism of Action of Blenrep

August 3, 2026 Harsh Singh Rajput

Introduction Blenrep is the brand name of belantamab mafodotin-blmf, an anticancer biologic used in relapsed or refractory multiple myeloma. Pharmacologically, Blenrep is a B-cell maturation antigen-directed antibody-drug conjugate, commonly called a BCMA-directed ADC. Multiple myeloma is a plasma-cell malignancy in which abnormal plasma cells multiply in the bone marrow and produce monoclonal immunoglobulin or light … Read more

Mechanism of Action of Dabrafenib

August 3, 2026 Harsh Singh Rajput

Introduction Dabrafenib is an oral targeted anticancer drug marketed under the brand name Tafinlar. Pharmacologically, dabrafenib is a BRAF kinase inhibitor used in selected cancers with activating BRAF mutations. The BRAF protein is a serine/threonine kinase in the RAS-RAF-MEK-ERK signaling pathway, also called the MAPK pathway. This pathway normally transmits growth signals from cell-surface receptors … Read more

Mechanism of Action of Teriflunomide

July 31, 2026 Harsh Singh Rajput

Introduction Teriflunomide is an oral immunomodulatory drug marketed under the brand name Aubagio. Pharmacologically, teriflunomide is a pyrimidine synthesis inhibitor used in multiple sclerosis. Multiple sclerosis, or MS, is a chronic immune-mediated disease of the central nervous system. In MS, autoreactive immune cells attack myelin, oligodendrocytes, and axonal structures in the brain and spinal cord. … Read more

Mechanism of Action of Dayvigo

July 31, 2026 Harsh Singh Rajput

Introduction Dayvigo is the brand name of lemborexant, an oral hypnotic drug used in adults with insomnia. Pharmacologically, lemborexant is an orexin receptor antagonist and belongs to the class of dual orexin receptor antagonists, commonly abbreviated as DORAs. Insomnia is characterized by difficulty falling asleep, difficulty staying asleep, or both. Many older hypnotic drugs promote … Read more