Introduction Ruxolitinib is an oral Janus kinase inhibitor used mainly in hematological and immune-mediated disorders. It is best known by the brand name Jakafi for systemic use, and it selectively inhibits Janus kinase 1 and Janus kinase 2, commonly called JAK1 and JAK2. Ruxolitinib is important in pharmacology because JAK enzymes are central mediators of … Read more
Introduction Kisqali is the brand name of ribociclib, an oral targeted anticancer drug used in hormone receptor-positive, HER2-negative breast cancer. It belongs to the class of cyclin-dependent kinase 4 and 6 inhibitors, commonly called CDK4/6 inhibitors. Kisqali is important in oncology pharmacology because it targets the cell cycle machinery that allows cancer cells to divide … Read more
Introduction Trintellix is the brand name of vortioxetine, an oral antidepressant used for the treatment of major depressive disorder in adults. It is commonly described as a multimodal serotonergic antidepressant because it affects serotonin reuptake and multiple serotonin receptor subtypes. Current prescribing information lists Trintellix as indicated for major depressive disorder in adults. Trintellix is … Read more
Introduction Caplyta is the brand name of lumateperone, an oral atypical antipsychotic used in adults for schizophrenia, depressive episodes associated with bipolar I or bipolar II disorder, and as adjunctive treatment with an antidepressant for major depressive disorder. It is not known whether Caplyta is safe and effective in children. Caplyta is important in pharmacology … Read more
Introduction Qelbree is the brand name of viloxazine extended-release, a non-stimulant drug used for the treatment of attention-deficit/hyperactivity disorder, commonly called ADHD. It is indicated for ADHD in adults and pediatric patients 6 years of age and older. Qelbree is pharmacologically important because it is different from stimulant ADHD medicines such as methylphenidate and amphetamine … Read more
Introduction Verquvo is the brand name of vericiguat, an oral soluble guanylate cyclase stimulator used in selected adults with symptomatic chronic heart failure. It is mainly used in patients with heart failure and ejection fraction less than 45% who have recently had worsening heart failure requiring hospitalization or outpatient intravenous diuretic therapy. Its clinical role … Read more
Introduction Cosentyx is the brand name of secukinumab, a fully human monoclonal antibody used in immune-mediated inflammatory diseases. It belongs to the class of interleukin-17A inhibitors, also called IL-17A antagonists. Cosentyx is important in pharmacology because it targets a specific inflammatory cytokine rather than producing broad immunosuppression like corticosteroids. It is used in conditions where … Read more
Introduction Rybelsus is the brand name of oral semaglutide, a glucagon-like peptide-1 receptor agonist used in the management of type 2 diabetes mellitus. It is pharmacologically important because it is an orally administered GLP-1 receptor agonist, unlike many other GLP-1 receptor agonists that are given by subcutaneous injection. Rybelsus is used along with diet and … Read more
Introduction Auvelity is a fixed-dose oral combination of dextromethorphan hydrobromide and bupropion hydrochloride. It is used for the treatment of major depressive disorder in adults, and its U.S. use has also expanded to agitation associated with dementia due to Alzheimer’s disease in adults. Auvelity is pharmacologically important because it combines two drugs with different but … Read more
Introduction Fasenra is the brand name of benralizumab, a humanized monoclonal antibody used mainly in the management of severe eosinophilic asthma. It belongs to the class of biologic anti-eosinophilic therapies and is especially important in patients whose asthma remains uncontrolled despite standard inhaled corticosteroid and long-acting bronchodilator therapy. Unlike conventional asthma medicines such as beta-2 … Read more
