Introduction Latuda is the brand name of lurasidone hydrochloride, an oral atypical antipsychotic drug. It is mainly used for schizophrenia and depressive episodes associated with bipolar I disorder. Pharmacologically, lurasidone is classified as a second-generation antipsychotic, also called an atypical antipsychotic. Lurasidone works by modulating dopamine and serotonin neurotransmission in the brain. The exact therapeutic … Read more
Introduction Tafamidis is an oral disease-modifying drug used for transthyretin amyloid cardiomyopathy, commonly abbreviated as ATTR-CM. It is marketed under the brand names Vyndaqel and Vyndamax. Pharmacologically, tafamidis is a transthyretin stabilizer. Transthyretin, or TTR, is a transport protein mainly produced by the liver. It normally circulates as a tetramer, meaning it is made of … Read more
Introduction Ponatinib is an oral targeted anticancer drug used in selected Philadelphia chromosome-positive leukemias. It is marketed under the brand name Iclusig. Pharmacologically, ponatinib belongs to the BCR-ABL tyrosine kinase inhibitor class and is often described as a third-generation BCR-ABL inhibitor. Philadelphia chromosome-positive chronic myeloid leukemia, or Ph+ CML, and Philadelphia chromosome-positive acute lymphoblastic leukemia, … Read more
Introduction Pegcetacoplan is a targeted complement inhibitor used in diseases driven by abnormal activation of the complement system. It is marketed as Empaveli for systemic use and as Syfovre for intravitreal ophthalmic use. Empaveli is used for adult patients with paroxysmal nocturnal hemoglobinuria, commonly called PNH, and is also indicated for adults and pediatric patients … Read more
Introduction Romosozumab is a humanized monoclonal antibody used for the treatment of osteoporosis in postmenopausal women who are at high risk of fracture. It is marketed under the brand name Evenity. Pharmacologically, romosozumab belongs to the sclerostin inhibitor class and is considered an anabolic bone-forming therapy with an additional antiresorptive effect. Osteoporosis is characterized by … Read more
Introduction Valbenazine is an oral drug used for the treatment of abnormal involuntary movements. It is marketed under the brand names Ingrezza and Ingrezza Sprinkle. Pharmacologically, valbenazine is a vesicular monoamine transporter 2 inhibitor, commonly abbreviated as a VMAT2 inhibitor. Valbenazine is mainly used in adults with tardive dyskinesia and chorea associated with Huntington’s disease. … Read more
Introduction Olaparib is an oral anticancer drug that belongs to the poly ADP-ribose polymerase inhibitor class, commonly called PARP inhibitors. It is marketed under the brand name Lynparza. Olaparib is an important targeted anticancer drug used in cancers with defects in DNA repair pathways, especially BRCA1, BRCA2, and other homologous recombination repair gene abnormalities. The … Read more
Introduction Cladribine is a purine nucleoside analogue used as an immunosuppressive and antineoplastic drug. It is available under important brand names such as Mavenclad for relapsing forms of multiple sclerosis and Leustatin for hairy cell leukemia. Pharmacologically, cladribine is an adenosine analogue that is resistant to degradation by adenosine deaminase, allowing it to persist inside … Read more
Introduction Brilinta is the brand name of ticagrelor, an oral antiplatelet drug used mainly to prevent thrombotic cardiovascular and cerebrovascular events. It belongs to the P2Y12 platelet receptor inhibitor class and is commonly used in patients with acute coronary syndrome, history of myocardial infarction, coronary artery disease at high risk of thrombotic events, and selected … Read more
Introduction Eltrombopag is an oral thrombopoietin receptor agonist used to increase platelet production in selected patients with thrombocytopenia. It is marketed under the brand name Promacta in the United States and Revolade in some other countries. Pharmacologically, eltrombopag is classified as a non-peptide thrombopoietin receptor agonist. Thrombopoietin, also called TPO, is the natural hormone that … Read more
