Mechanism of Action of Taltz Introduction Taltz is the brand name of ixekizumab, a biologic immunomodulator used in selected chronic inflammatory diseases. Pharmacologically, ixekizumab is a humanized immunoglobulin G4 monoclonal antibody that acts as an interleukin-17A antagonist. Interleukin-17A, commonly called IL-17A, is a pro-inflammatory cytokine involved in normal immune defense and abnormal immune-mediated inflammation. It … Read more
Introduction Enbrel is the brand name of etanercept, a biologic disease-modifying antirheumatic drug used in several chronic inflammatory autoimmune diseases. Pharmacologically, etanercept is a tumor necrosis factor blocker, commonly called a TNF inhibitor or anti-TNF drug. Tumor necrosis factor, especially TNF-alpha, is a major pro-inflammatory cytokine involved in immune activation, leukocyte migration, synovial inflammation, cartilage … Read more
Introduction Secukinumab is a biologic immunomodulator marketed under the brand name Cosentyx. Pharmacologically, it is a human interleukin-17A antagonist and a recombinant human IgG1 kappa monoclonal antibody. Interleukin-17A, commonly called IL-17A, is a pro-inflammatory cytokine involved in immune defense and chronic inflammatory disease. It is produced mainly by Th17 cells, but other immune cells such … Read more
Introduction Guselkumab is a biologic immunomodulator used in inflammatory immune-mediated diseases. It is marketed under the brand name Tremfya. Pharmacologically, guselkumab is an interleukin-23 antagonist and a human IgG1 lambda monoclonal antibody. Interleukin-23, commonly called IL-23, is an important cytokine involved in chronic inflammation. It plays a major role in the activation and maintenance of … Read more
Introduction Canakinumab is a recombinant human monoclonal antibody used as a targeted anti-inflammatory biologic. It is marketed under the brand name Ilaris and belongs to the class of interleukin-1 beta inhibitors. Canakinumab specifically blocks interleukin-1 beta, also written as IL-1β, a powerful pro-inflammatory cytokine involved in fever, neutrophil recruitment, acute-phase response, joint inflammation, systemic inflammation, … Read more
Introduction Belimumab is a human IgG1λ monoclonal antibody used in the treatment of autoimmune lupus disorders. It is marketed under the brand name Benlysta and is classified as a B-lymphocyte stimulator-specific inhibitor, also called a BLyS inhibitor or BAFF inhibitor. Belimumab is used in patients 5 years of age and older with active systemic lupus … Read more
