Introduction Lurbinectedin is an intravenous anticancer drug marketed under the brand name Zepzelca. It belongs to the class of alkylating antineoplastic agents and is mainly used in small cell lung cancer, a highly aggressive neuroendocrine lung cancer that often responds initially to platinum-based chemotherapy but commonly relapses. Lurbinectedin is pharmacologically important because it targets DNA … Read more
Introduction Ibrance is the brand name of palbociclib, an oral targeted anticancer drug belonging to the class of cyclin-dependent kinase 4 and 6 inhibitors, commonly called CDK4/6 inhibitors. It is mainly used in hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced or metastatic breast cancer. Ibrance is pharmacologically important because it targets a key … Read more
Introduction Mavacamten is an oral cardiac myosin inhibitor marketed under the brand name Camzyos. It is used for the treatment of adults with symptomatic New York Heart Association class II–III obstructive hypertrophic cardiomyopathy, also called obstructive HCM or oHCM, to improve functional capacity and symptoms. Current prescribing information describes Camzyos as a cardiac myosin inhibitor … Read more
Introduction Canakinumab is a recombinant human monoclonal antibody used as a targeted anti-inflammatory biologic. It is marketed under the brand name Ilaris and belongs to the class of interleukin-1 beta inhibitors. Canakinumab specifically blocks interleukin-1 beta, also written as IL-1β, a powerful pro-inflammatory cytokine involved in fever, neutrophil recruitment, acute-phase response, joint inflammation, systemic inflammation, … Read more
Introduction Xiidra is the brand name of lifitegrast ophthalmic solution 5%, a prescription eye drop used for the treatment of signs and symptoms of dry eye disease. Dry eye disease is a chronic inflammatory condition of the ocular surface in which tear film instability, inflammation, epithelial stress, and immune-cell activation contribute to dryness, burning, irritation, … Read more
Introduction Opzelura is the brand name of ruxolitinib cream, a topical Janus kinase inhibitor used in inflammatory and autoimmune skin diseases. It contains ruxolitinib phosphate and is available as a 1.5% cream for application to affected skin areas. Opzelura is indicated for the short-term and non-continuous chronic treatment of mild to moderate atopic dermatitis in … Read more
Introduction Vtama is the brand name of tapinarof cream 1%, a topical non-steroidal dermatological drug used in inflammatory skin diseases. It belongs to the class of aryl hydrocarbon receptor agonists, commonly abbreviated as AhR agonists. Vtama is indicated for the topical treatment of plaque psoriasis in adults and atopic dermatitis in adults and pediatric patients … Read more
Introduction Dasatinib is an oral targeted anticancer drug belonging to the class of tyrosine kinase inhibitors. It is best known by the brand name Sprycel and is mainly used in Philadelphia chromosome-positive leukemias, especially chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia. The Philadelphia chromosome results from a translocation between chromosomes 9 and 22, … Read more
Introduction Uplizna is the brand name of inebilizumab-cdon, a CD19-directed humanized monoclonal antibody used in selected autoimmune neurological and immune-mediated diseases. It belongs to the class of B-cell-depleting biologic therapies. Uplizna is indicated in adults for anti-aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder, immunoglobulin G4-related disease, and generalized myasthenia gravis in patients who are anti-acetylcholine receptor … Read more
Introduction Belimumab is a human IgG1λ monoclonal antibody used in the treatment of autoimmune lupus disorders. It is marketed under the brand name Benlysta and is classified as a B-lymphocyte stimulator-specific inhibitor, also called a BLyS inhibitor or BAFF inhibitor. Belimumab is used in patients 5 years of age and older with active systemic lupus … Read more
