endometriosis - Pharmacy Freak

Mechanism of Action of Relugolix

July 23, 2026 Harsh Singh Rajput

Introduction Relugolix is an oral gonadotropin-releasing hormone receptor antagonist, also called a GnRH receptor antagonist or LHRH receptor antagonist. It is used as relugolix alone under the brand name Orgovyx for adult patients with advanced prostate cancer. Relugolix is also present in the combination product Myfembree, which contains relugolix, estradiol, and norethindrone acetate for selected … Read more

Mechanism of Action of Leuprolide (Lupron)

April 10, 2026July 16, 2025 Pharmacy Freak Editorial Team Harsh Singh Rajput

Introduction Leuprolide is a synthetic gonadotropin-releasing hormone (GnRH) agonist used in conditions like prostate cancer, endometriosis, uterine fibroids, and central precocious puberty. Initially, it stimulates the pituitary gland, but with continuous use, it leads to receptor desensitization, suppressing gonadotropins and resulting in decreased sex hormone levels. Step-by-Step Mechanism of Action Pharmacokinetic Parameters Parameter Value Route … Read more