Introduction Selinexor is an oral targeted anticancer drug belonging to the class of selective inhibitors of nuclear export, commonly called SINE compounds. It is marketed under the brand name Xpovio and is mainly used in selected patients with relapsed or refractory multiple myeloma. Current prescribing information lists selinexor as a nuclear export inhibitor indicated in … Read more
Introduction Promacta is the brand name of eltrombopag, an orally active thrombopoietin receptor agonist used to increase platelet production in selected patients with thrombocytopenia. It is especially important in conditions where platelet counts are low enough to increase bleeding risk. Promacta is used in persistent or chronic immune thrombocytopenia, thrombocytopenia associated with chronic hepatitis C … Read more
Introduction Alpelisib is an oral targeted anticancer drug that belongs to the class of phosphatidylinositol-3-kinase inhibitors. It is mainly known as a selective PI3K alpha inhibitor and is used in diseases driven by activating mutations in the PIK3CA gene. In oncology, alpelisib is used in combination with fulvestrant for patients with hormone receptor-positive, HER2-negative, PIK3CA-mutated … Read more
Introduction Zeposia is the brand name of ozanimod, an oral immunomodulatory drug used mainly in relapsing forms of multiple sclerosis and moderately to severely active ulcerative colitis. It belongs to the class of sphingosine-1-phosphate receptor modulators, commonly called S1P receptor modulators. Zeposia is important in pharmacology because it does not act like a conventional anti-inflammatory … Read more
Introduction Zolpidem is a non-benzodiazepine sedative-hypnotic drug primarily used for the short-term treatment of insomnia. It belongs to a class of medications commonly referred to as “Z-drugs,” which also includes zaleplon and zopiclone/eszopiclone. Although structurally different from benzodiazepines, zolpidem exerts its pharmacological effects through the gamma-aminobutyric acid (GABA) neurotransmitter system. Zolpidem is particularly effective in … Read more
Introduction Verapamil is a non-dihydropyridine calcium channel blocker (CCB) that is widely used in the treatment of hypertension, angina pectoris, and supraventricular arrhythmias. Unlike dihydropyridine calcium channel blockers that primarily act on vascular smooth muscle, verapamil exerts significant effects on both cardiac muscle and the cardiac conduction system. By inhibiting L-type calcium channels in the … Read more
Introduction Tizanidine is a centrally acting skeletal muscle relaxant used primarily for the management of spasticity associated with conditions such as multiple sclerosis, spinal cord injury, stroke, and other neurological disorders. It reduces excessive muscle tone by inhibiting excitatory neurotransmission within the central nervous system. Unlike neuromuscular blocking agents, tizanidine acts at the spinal cord … Read more
Introduction Tricyclic antidepressants (TCAs) are a class of antidepressant drugs used in major depressive disorder, neuropathic pain, migraine prophylaxis, obsessive-compulsive disorder, and certain anxiety disorders. Common TCAs include amitriptyline, nortriptyline, imipramine, desipramine, and clomipramine. Their primary action is inhibition of serotonin and norepinephrine reuptake, leading to increased concentrations of these neurotransmitters in the central nervous … Read more
Pharmacy Freak · NIPER General Knowledge and Computer Awareness Subject-wise Mock Test NIPER General Knowledge and Computer Awareness Mock Test Practice General Knowledge and Computer Awareness for NIPER JEE with 50 single-best-answer MCQs in 38 minutes. Full marks: 25. Marking: +0.5 correct / -0.125 incorrect. Unanswered questions carry 0 marks. Auto-submits at 00:00. Questions 50 … Read more
M Pharm · Regulatory Affairs Regulations and Legislation for Drugs and Cosmetics, Medical Devices, Biologicals and Herbals, and Food and Nutraceuticals In India and Intellectual Property Rights MCQs with answers Free, chapter-wise MCQs covering Indian drug and cosmetic laws, medical device rules, biologics, herbals, food and nutraceutical regulations, regulatory filing, clinical trial requirements, pharmacovigilance and … Read more
