Introduction Cimzia is the brand name of certolizumab pegol, a biologic anti-inflammatory drug used in several immune-mediated inflammatory diseases. Pharmacologically, Cimzia is a tumor necrosis factor blocker, commonly called a TNF inhibitor or anti-TNF drug. Tumor necrosis factor-alpha, or TNF-alpha, is a major pro-inflammatory cytokine involved in immune-cell activation, cytokine release, leukocyte migration, endothelial activation, … Read more
Introduction Enbrel is the brand name of etanercept, a biologic disease-modifying antirheumatic drug used in several chronic inflammatory autoimmune diseases. Pharmacologically, etanercept is a tumor necrosis factor blocker, commonly called a TNF inhibitor or anti-TNF drug. Tumor necrosis factor, especially TNF-alpha, is a major pro-inflammatory cytokine involved in immune activation, leukocyte migration, synovial inflammation, cartilage … Read more
Introduction Etanercept is a biologic fusion protein that functions as a soluble tumor necrosis factor (TNF) receptor. By binding TNF-α and TNF-β in circulation, it blocks their interaction with cell surface receptors, reducing systemic inflammation. It is approved for rheumatoid arthritis (RA), psoriatic arthritis (PsA), ankylosing spondylitis (AS), juvenile idiopathic arthritis (JIA), and plaque psoriasis. … Read more
