Introduction Ultomiris is the brand name of ravulizumab-cwvz, a long-acting complement inhibitor. Pharmacologically, ravulizumab is a humanized monoclonal antibody that binds complement protein C5 and prevents terminal complement activation. The complement system is part of innate immunity. It helps destroy pathogens and damaged cells through inflammatory mediators and formation of the membrane attack complex, also … Read more
Introduction Vyvgart is the brand name of efgartigimod alfa-fcab, an immunomodulatory biologic drug used for generalized myasthenia gravis, commonly abbreviated as gMG. Pharmacologically, Vyvgart is a neonatal Fc receptor blocker, also called an FcRn blocker. A related subcutaneous product, Vyvgart Hytrulo, contains efgartigimod alfa with hyaluronidase-qvfc and is used in adults with generalized myasthenia gravis … Read more
Introduction Uplizna is the brand name of inebilizumab-cdon, a CD19-directed humanized monoclonal antibody used in selected autoimmune neurological and immune-mediated diseases. It belongs to the class of B-cell-depleting biologic therapies. Uplizna is indicated in adults for anti-aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder, immunoglobulin G4-related disease, and generalized myasthenia gravis in patients who are anti-acetylcholine receptor … Read more
