partial agonist - Pharmacy Freak

Mechanism of Action of Cariprazine

August 12, 2026August 8, 2026 Harsh Singh Rajput

Introduction Cariprazine is an oral atypical antipsychotic marketed under the brand name Vraylar. Pharmacologically, cariprazine is a dopamine-serotonin receptor modulator with partial agonist activity at dopamine D3 and D2 receptors and serotonin 5-HT1A receptors, plus antagonist activity at serotonin 5-HT2A receptors. Psychiatric disorders such as schizophrenia, bipolar I disorder, and major depressive disorder involve complex … Read more

Mechanism of Action of Aripiprazole

April 10, 2026July 13, 2025 Pharmacy Freak Editorial Team Harsh Singh Rajput

Introduction Aripiprazole is a third-generation atypical antipsychotic approved for treating schizophrenia, bipolar disorder, depression (as an adjunct), Tourette’s syndrome, and irritability in autism. It is pharmacologically unique for its role as a partial agonist at dopamine D₂ and serotonin 5‑HT₁A receptors, and as an antagonist at serotonin 5‑HT₂A receptors, allowing it to modulate neurotransmission rather … Read more