Introduction Belimumab is a human IgG1λ monoclonal antibody used in the treatment of autoimmune lupus disorders. It is marketed under the brand name Benlysta and is classified as a B-lymphocyte stimulator-specific inhibitor, also called a BLyS inhibitor or BAFF inhibitor. Belimumab is used in patients 5 years of age and older with active systemic lupus … Read more
Introduction Cosentyx is the brand name of secukinumab, a fully human monoclonal antibody used in immune-mediated inflammatory diseases. It belongs to the class of interleukin-17A inhibitors, also called IL-17A antagonists. Cosentyx is important in pharmacology because it targets a specific inflammatory cytokine rather than producing broad immunosuppression like corticosteroids. It is used in conditions where … Read more
Introduction Fasenra is the brand name of benralizumab, a humanized monoclonal antibody used mainly in the management of severe eosinophilic asthma. It belongs to the class of biologic anti-eosinophilic therapies and is especially important in patients whose asthma remains uncontrolled despite standard inhaled corticosteroid and long-acting bronchodilator therapy. Unlike conventional asthma medicines such as beta-2 … Read more
Introduction Eculizumab is a humanized monoclonal antibody that selectively binds to complement protein C5, inhibiting its cleavage and preventing terminal complement complex formation. It is approved for paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS), generalized myasthenia gravis (gMG), and neuromyelitis optica spectrum disorder (NMOSD). Step-by-Step Mechanism of Action Pharmacokinetic Parameters Parameter Value Route … Read more
