Mechanism of Action of Sarilumab
Introduction Sarilumab is a biologic immunomodulatory drug marketed under the brand name Kevzara. Pharmacologically, sarilumab is an interleukin-6 receptor antagonist, commonly called an IL-6 receptor blocker. Interleukin-6, or IL-6, is a pro-inflammatory cytokine involved in immune-cell activation, acute-phase inflammation, antibody production, hepatic acute-phase protein synthesis, hematopoiesis, fever, systemic inflammation, and synovial inflammation. Excessive IL-6 signaling … Read more