Introduction Tenapanor is an oral, locally acting gastrointestinal drug marketed under two important brand names: Ibsrela and Xphozah. Pharmacologically, tenapanor is a sodium/hydrogen exchanger 3 inhibitor, commonly written as an NHE3 inhibitor. NHE3 is an antiporter located on the apical surface of intestinal epithelial cells in the small intestine and colon. It plays an important … Read more
Introduction Lubiprostone is a chloride channel activator used primarily to manage chronic idiopathic constipation, irritable bowel syndrome with constipation (IBS-C), and opioid-induced constipation. Unlike traditional laxatives, lubiprostone targets specific ion channels on the gastrointestinal epithelium to enhance fluid secretion and promote intestinal motility. This unique mechanism ensures more physiologic bowel movements with minimal systemic absorption. … Read more
