Mechanism of Action - Pharmacy Freak

Mechanism of Action of Avacopan

July 30, 2026 Harsh Singh Rajput

Introduction Avacopan is an oral immunology drug marketed under the brand name Tavneos. Pharmacologically, avacopan is a complement 5a receptor antagonist, commonly written as a C5aR antagonist. Anti-neutrophil cytoplasmic autoantibody-associated vasculitis, or ANCA-associated vasculitis, is an autoimmune small-vessel vasculitis. It includes granulomatosis with polyangiitis, also called GPA, and microscopic polyangiitis, also called MPA. In these … Read more

Mechanism of Action of Suvorexant

July 30, 2026 Harsh Singh Rajput

Introduction Suvorexant is an oral hypnotic drug marketed under the brand name Belsomra. Pharmacologically, suvorexant is a dual orexin receptor antagonist, commonly called a DORA. Insomnia is a sleep disorder characterized by difficulty falling asleep, difficulty staying asleep, or both. Unlike traditional sedative-hypnotic drugs that broadly depress the central nervous system through GABAergic mechanisms, suvorexant … Read more

Mechanism of Action of Camzyos

July 29, 2026 Harsh Singh Rajput

Introduction Camzyos is the brand name of mavacamten, an oral cardiac myosin inhibitor used in obstructive hypertrophic cardiomyopathy, commonly called obstructive HCM or oHCM. Hypertrophic cardiomyopathy is a disease in which the heart muscle, especially the left ventricle, becomes abnormally thickened. In obstructive HCM, the thickened septum and abnormal ventricular contraction can narrow the left … Read more

Mechanism of Action of Asciminib

July 29, 2026 Harsh Singh Rajput

Introduction Asciminib is an oral targeted anticancer drug marketed under the brand name Scemblix. Pharmacologically, asciminib is an ABL/BCR-ABL1 tyrosine kinase inhibitor used in Philadelphia chromosome-positive chronic myeloid leukemia, commonly abbreviated as Ph+ CML. Chronic myeloid leukemia is driven by the Philadelphia chromosome, which forms due to a translocation between chromosomes 9 and 22. This … Read more

Mechanism of Action of Ultomiris

July 28, 2026 Harsh Singh Rajput

Introduction Ultomiris is the brand name of ravulizumab-cwvz, a long-acting complement inhibitor. Pharmacologically, ravulizumab is a humanized monoclonal antibody that binds complement protein C5 and prevents terminal complement activation. The complement system is part of innate immunity. It helps destroy pathogens and damaged cells through inflammatory mediators and formation of the membrane attack complex, also … Read more

Mechanism of Action of Apalutamide

July 28, 2026 Harsh Singh Rajput

Introduction Apalutamide is an oral targeted anticancer drug marketed under the brand name Erleada. Pharmacologically, apalutamide is an androgen receptor inhibitor used in prostate cancer. Prostate cancer growth is often driven by androgen signaling. Androgens such as testosterone and dihydrotestosterone bind to androgen receptors inside prostate cancer cells. Once activated, androgen receptors move into the … Read more

Mechanism of Action of Fostamatinib

July 27, 2026 Harsh Singh Rajput

Introduction Fostamatinib is an oral targeted drug marketed under the brand name Tavalisse. Pharmacologically, fostamatinib is a spleen tyrosine kinase inhibitor, commonly called a SYK inhibitor. Immune thrombocytopenia, or ITP, is an autoimmune bleeding disorder in which platelets are destroyed faster than they can be replaced. In chronic ITP, autoantibodies bind to platelets and mark … Read more

Mechanism of Action of Ingrezza

July 27, 2026 Harsh Singh Rajput

Introduction Ingrezza is the brand name of valbenazine, an oral drug used for movement disorders caused by abnormal monoamine signaling in the brain. Pharmacologically, valbenazine is a vesicular monoamine transporter 2 inhibitor, commonly called a VMAT2 inhibitor. VMAT2 is a transporter present on synaptic vesicles inside presynaptic neurons. Its normal role is to move monoamine … Read more

Mechanism of Action of Solriamfetol

July 25, 2026 Harsh Singh Rajput

Introduction Solriamfetol is an oral wakefulness-promoting drug marketed under the brand name Sunosi. Pharmacologically, solriamfetol is a dopamine and norepinephrine reuptake inhibitor, commonly abbreviated as DNRI. Excessive daytime sleepiness is a major symptom in narcolepsy and obstructive sleep apnea. In narcolepsy, sleep-wake regulation is disturbed, often due to abnormalities in wake-promoting and REM sleep-regulating pathways. … Read more

Mechanism of Action of Tysabri

July 25, 2026 Harsh Singh Rajput

Introduction Tysabri is the brand name of natalizumab, a biologic immunomodulator used mainly in multiple sclerosis and Crohn’s disease. Pharmacologically, natalizumab is a recombinant humanized IgG4 monoclonal antibody that targets alpha-4 integrin. Alpha-4 integrins are adhesion molecules found on the surface of many leukocytes. These molecules help immune cells attach to blood vessel walls and … Read more