Mechanism of Action of Spravato
Introduction Spravato is the brand name of esketamine, a nasal spray antidepressant used in selected adults with major depressive disorder. Pharmacologically, esketamine is a non-selective, non-competitive N-methyl-D-aspartate receptor antagonist, commonly called an NMDA receptor antagonist. Depression is a complex psychiatric disorder involving mood, cognition, sleep, appetite, motivation, reward processing, stress regulation, neuroplasticity, and multiple neurotransmitter … Read more