overactive bladder pharmacology

Mechanism of Action of Gemtesa

August 10, 2026 Harsh Singh Rajput

Introduction Gemtesa is the brand name of vibegron, an oral drug used for overactive bladder. Pharmacologically, vibegron is a selective beta-3 adrenergic receptor agonist. Overactive bladder, commonly abbreviated as OAB, is a urinary bladder disorder characterized by urgency, frequency, nocturia, and sometimes urge urinary incontinence. Urgency means a sudden strong desire to pass urine. Urge … Read more

Mechanism of Action of Mirabegron

April 10, 2026July 13, 2025 Pharmacy Freak Editorial Team Harsh Singh Rajput

Introduction Mirabegron is a β₃‑adrenergic receptor agonist used to treat overactive bladder (OAB). By selectively activating β₃‑receptors in the detrusor muscle of the bladder, it enhances urine storage and reduces urinary urgency and frequency without significantly affecting cardiovascular β₁ or β₂ receptors. Step-by-Step Mechanism of Action Pharmacokinetic Parameters Parameter Value Bioavailability ~29% (fasting) Peak Plasma … Read more