Introduction Rybrevant is the brand name of amivantamab-vmjw, an anticancer biologic used in selected patients with non-small cell lung cancer, commonly abbreviated as NSCLC. Pharmacologically, Rybrevant is a bispecific antibody directed against two important receptor targets: epidermal growth factor receptor, or EGFR, and MET receptor. NSCLC is a major type of lung cancer. In some … Read more
Introduction Dabrafenib is an oral targeted anticancer drug marketed under the brand name Tafinlar. Pharmacologically, dabrafenib is a BRAF kinase inhibitor used in selected cancers with activating BRAF mutations. The BRAF protein is a serine/threonine kinase in the RAS-RAF-MEK-ERK signaling pathway, also called the MAPK pathway. This pathway normally transmits growth signals from cell-surface receptors … Read more
Introduction Sotorasib is an oral targeted anticancer drug marketed under the brand name Lumakras. Pharmacologically, sotorasib is a KRAS G12C inhibitor and belongs to the class of RAS GTPase inhibitors. KRAS is an important intracellular signaling protein involved in cell growth, proliferation, differentiation, survival, and apoptosis regulation. Normally, KRAS works like a molecular switch. It … Read more
