Introduction Sandostatin is the brand name of octreotide, a synthetic somatostatin analogue. It is a cyclic octapeptide designed to reproduce many of the inhibitory actions of the natural hormone somatostatin while having a much longer duration of action. Somatostatin is an endogenous peptide hormone that suppresses the secretion of several hormones and gastrointestinal mediators. Octreotide … Read more
Introduction Octreotide is a synthetic somatostatin analog used to treat acromegaly, carcinoid syndrome, VIPoma, and control of panhormonal secretion. It mimics somatostatin, binding to somatostatin receptors (SSTRs), especially SSTR2, to inhibit hormone release and reduce symptoms caused by hormone-secreting tumors. Step-by-Step Mechanism of Action Pharmacokinetic Parameters Parameter Value Administration Subcutaneous/Intramuscular/Long-acting IM Bioavailability ~75–100% for SC … Read more
