Mechanism of Action of Jakafi
Introduction Jakafi is the brand name of ruxolitinib, an oral small-molecule kinase inhibitor that primarily inhibits Janus-associated kinase 1 (JAK1) and Janus-associated kinase 2 (JAK2). JAK1 and JAK2 are intracellular tyrosine kinases that transmit signals from numerous cytokine and growth-factor receptors to the nucleus. These signals are important for hematopoiesis, inflammation, and immune function. Ruxolitinib … Read more