Harsh Singh Rajput 
Introduction Sotorasib is an oral targeted anticancer drug marketed under the brand name Lumakras. Pharmacologically, sotorasib is a KRAS G12C inhibitor and belongs to the class of RAS GTPase inhibitors. KRAS is an important intracellular signaling protein involved in cell growth, proliferation, differentiation, survival, and apoptosis regulation. Normally, KRAS works like a molecular switch. It … Read more
Introduction Axitinib is an oral targeted anticancer drug marketed under the brand name Inlyta. Pharmacologically, axitinib is a receptor tyrosine kinase inhibitor that mainly blocks vascular endothelial growth factor receptors, also called VEGFRs. Renal cell carcinoma is a highly vascular tumor, meaning it depends strongly on blood vessel formation for growth and spread. Tumor cells … Read more
Introduction Cimzia is the brand name of certolizumab pegol, a biologic anti-inflammatory drug used in several immune-mediated inflammatory diseases. Pharmacologically, Cimzia is a tumor necrosis factor blocker, commonly called a TNF inhibitor or anti-TNF drug. Tumor necrosis factor-alpha, or TNF-alpha, is a major pro-inflammatory cytokine involved in immune-cell activation, cytokine release, leukocyte migration, endothelial activation, … Read more
Introduction Relugolix is an oral gonadotropin-releasing hormone receptor antagonist, also called a GnRH receptor antagonist or LHRH receptor antagonist. It is used as relugolix alone under the brand name Orgovyx for adult patients with advanced prostate cancer. Relugolix is also present in the combination product Myfembree, which contains relugolix, estradiol, and norethindrone acetate for selected … Read more
Introduction Ocrelizumab is a monoclonal antibody used in multiple sclerosis. It is marketed as Ocrevus for intravenous infusion. Ocrelizumab is also the active anti-CD20 antibody component in Ocrevus Zunovo, a subcutaneous formulation that contains ocrelizumab with hyaluronidase. Pharmacologically, ocrelizumab is a CD20-directed cytolytic monoclonal antibody. It is designed to target CD20-positive B lymphocytes, which are … Read more
Introduction Palbociclib is an oral targeted anticancer drug marketed under the brand name Ibrance. Pharmacologically, palbociclib is a cyclin-dependent kinase 4 and 6 inhibitor, commonly called a CDK4/6 inhibitor. Cell-cycle control is one of the most important concepts in cancer pharmacology. Normal cells divide only after receiving controlled growth signals. Cancer cells often escape these … Read more
Introduction Trulicity is the brand name of dulaglutide, a once-weekly injectable antidiabetic medicine used in type 2 diabetes mellitus. Pharmacologically, dulaglutide is a glucagon-like peptide-1 receptor agonist, commonly called a GLP-1 receptor agonist. GLP-1 is an incretin hormone released from intestinal L-cells after food intake. It helps regulate blood glucose by increasing insulin secretion, decreasing … Read more
Introduction Lumateperone is an oral atypical antipsychotic marketed under the brand name Caplyta. It is used in adults for schizophrenia, depressive episodes associated with bipolar I or bipolar II disorder, and as adjunctive therapy with antidepressants for major depressive disorder. The current U.S. prescribing information lists the recommended Caplyta dose as 42 mg orally once … Read more
Introduction Rexulti is the brand name of brexpiprazole, an oral atypical antipsychotic used in psychiatric and neuropsychiatric conditions. Pharmacologically, brexpiprazole is a serotonin-dopamine activity modulator with partial agonist activity at dopamine D2 and serotonin 5-HT1A receptors, along with antagonist activity at serotonin 5-HT2A receptors. Rexulti is used as adjunctive therapy with antidepressants for major depressive … Read more
Mechanism of Action of Taltz Introduction Taltz is the brand name of ixekizumab, a biologic immunomodulator used in selected chronic inflammatory diseases. Pharmacologically, ixekizumab is a humanized immunoglobulin G4 monoclonal antibody that acts as an interleukin-17A antagonist. Interleukin-17A, commonly called IL-17A, is a pro-inflammatory cytokine involved in normal immune defense and abnormal immune-mediated inflammation. It … Read more
