Harsh Singh Rajput

Harsh Singh Rajput is a pharmacist currently working at ESIC and holds an MBA in Pharmaceutical Management from NIPER Hyderabad. He has a strong academic record with top ranks in national-level pharmacy exams, including AIR 61 in NIPER 2024 (MS/M.Pharm), AIR 27 in NIPER MBA, AIR 147 in GPAT 2024, AIR 907 in GPAT 2023, and AIR 6 in AIIMS CRE-2025 for Drug Store Keeper. At PharmacyFreak.com, he contributes expert content, exam strategies, and practical guidance for future pharmacists. Mail- harsh@pharmacyfreak.com

Mechanism of Action of Kesimpta

July 13, 2026 Harsh Singh Rajput

Introduction Kesimpta is the brand name of ofatumumab, a subcutaneous monoclonal antibody used for relapsing forms of multiple sclerosis. Pharmacologically, Kesimpta is a CD20-directed cytolytic antibody. It is used in adults with relapsing forms of multiple sclerosis, including clinically isolated syndrome, relapsing-remitting multiple sclerosis, and active secondary progressive multiple sclerosis. Multiple sclerosis is an immune-mediated … Read more

Mechanism of Action of Latuda

July 12, 2026 Harsh Singh Rajput

Introduction Latuda is the brand name of lurasidone hydrochloride, an oral atypical antipsychotic drug. It is mainly used for schizophrenia and depressive episodes associated with bipolar I disorder. Pharmacologically, lurasidone is classified as a second-generation antipsychotic, also called an atypical antipsychotic. Lurasidone works by modulating dopamine and serotonin neurotransmission in the brain. The exact therapeutic … Read more

Mechanism of Action of Tafamidis

July 12, 2026 Harsh Singh Rajput

Introduction Tafamidis is an oral disease-modifying drug used for transthyretin amyloid cardiomyopathy, commonly abbreviated as ATTR-CM. It is marketed under the brand names Vyndaqel and Vyndamax. Pharmacologically, tafamidis is a transthyretin stabilizer. Transthyretin, or TTR, is a transport protein mainly produced by the liver. It normally circulates as a tetramer, meaning it is made of … Read more

Mechanism of Action of Ponatinib

July 12, 2026 Harsh Singh Rajput

Introduction Ponatinib is an oral targeted anticancer drug used in selected Philadelphia chromosome-positive leukemias. It is marketed under the brand name Iclusig. Pharmacologically, ponatinib belongs to the BCR-ABL tyrosine kinase inhibitor class and is often described as a third-generation BCR-ABL inhibitor. Philadelphia chromosome-positive chronic myeloid leukemia, or Ph+ CML, and Philadelphia chromosome-positive acute lymphoblastic leukemia, … Read more

Mechanism of Action of Pegcetacoplan

July 12, 2026 Harsh Singh Rajput

Introduction Pegcetacoplan is a targeted complement inhibitor used in diseases driven by abnormal activation of the complement system. It is marketed as Empaveli for systemic use and as Syfovre for intravitreal ophthalmic use. Empaveli is used for adult patients with paroxysmal nocturnal hemoglobinuria, commonly called PNH, and is also indicated for adults and pediatric patients … Read more

Mechanism of Action of Romosozumab

July 9, 2026 Harsh Singh Rajput

Introduction Romosozumab is a humanized monoclonal antibody used for the treatment of osteoporosis in postmenopausal women who are at high risk of fracture. It is marketed under the brand name Evenity. Pharmacologically, romosozumab belongs to the sclerostin inhibitor class and is considered an anabolic bone-forming therapy with an additional antiresorptive effect. Osteoporosis is characterized by … Read more

Mechanism of Action of Abemaciclib

July 9, 2026 Harsh Singh Rajput

Introduction Abemaciclib is an oral targeted anticancer drug used mainly in hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancer. It is marketed under the brand name Verzenio. Pharmacologically, abemaciclib belongs to the cyclin-dependent kinase 4 and 6 inhibitor class, commonly abbreviated as CDK4/6 inhibitors. CDK4 and CDK6 are important enzymes involved in cell-cycle … Read more

Mechanism of Action of Valbenazine

July 8, 2026 Harsh Singh Rajput

Introduction Valbenazine is an oral drug used for the treatment of abnormal involuntary movements. It is marketed under the brand names Ingrezza and Ingrezza Sprinkle. Pharmacologically, valbenazine is a vesicular monoamine transporter 2 inhibitor, commonly abbreviated as a VMAT2 inhibitor. Valbenazine is mainly used in adults with tardive dyskinesia and chorea associated with Huntington’s disease. … Read more

Mechanism of Action of Olaparib

July 8, 2026 Harsh Singh Rajput

Introduction Olaparib is an oral anticancer drug that belongs to the poly ADP-ribose polymerase inhibitor class, commonly called PARP inhibitors. It is marketed under the brand name Lynparza. Olaparib is an important targeted anticancer drug used in cancers with defects in DNA repair pathways, especially BRCA1, BRCA2, and other homologous recombination repair gene abnormalities. The … Read more

Mechanism of Action of Nilotinib

July 7, 2026 Harsh Singh Rajput

Introduction Nilotinib is an oral anticancer drug used mainly in Philadelphia chromosome-positive chronic myeloid leukemia, commonly abbreviated as Ph+ CML. It belongs to the BCR-ABL tyrosine kinase inhibitor class. The most widely known brand name is Tasigna, and another formulation is Danziten. Nilotinib is pharmacologically related to imatinib but was designed to bind the BCR-ABL … Read more