Introduction Alpelisib is an oral targeted anticancer drug that belongs to the class of phosphatidylinositol-3-kinase inhibitors. It is mainly known as a selective PI3K alpha inhibitor and is used in diseases driven by activating mutations in the PIK3CA gene. In oncology, alpelisib is used in combination with fulvestrant for patients with hormone receptor-positive, HER2-negative, PIK3CA-mutated … Read more
Introduction Trodelvy is the brand name for sacituzumab govitecan, an antibody-drug conjugate (ADC) used for the treatment of certain advanced or metastatic cancers, particularly triple-negative breast cancer (TNBC) and hormone receptor-positive/HER2-negative breast cancer after prior therapies. It combines the targeting capability of a monoclonal antibody with the potent cytotoxic activity of a chemotherapy payload. Sacituzumab … Read more
Introduction Bleomycin is a cytotoxic glycopeptide antibiotic used as an antineoplastic agent, especially in the treatment of Hodgkin lymphoma, testicular cancer, squamous cell carcinomas, and germ cell tumors. It is unique among chemotherapeutic agents because it causes minimal myelosuppression but is strongly associated with pulmonary toxicity. Bleomycin acts primarily during the G2 phase of the … Read more
