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Mechanism of Action of Uplizna

Mechanism of Action of Uplizna

Introduction Uplizna is the brand name of inebilizumab-cdon, a CD19-directed humanized monoclonal antibody used in selected autoimmune neurological and immune-mediated diseases. It belongs to the class of B-cell-depleting biologic therapies. Uplizna is indicated in adults for anti-aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder, immunoglobulin G4-related disease, and generalized myasthenia gravis in patients who are anti-acetylcholine receptor … Read more

Mechanism of Action of Eculizumab (Soliris)

Mechanism of action of Eculizumab

Introduction Eculizumab is a humanized monoclonal antibody that selectively binds to complement protein C5, inhibiting its cleavage and preventing terminal complement complex formation. It is approved for paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS), generalized myasthenia gravis (gMG), and neuromyelitis optica spectrum disorder (NMOSD). Step-by-Step Mechanism of Action Pharmacokinetic Parameters Parameter Value Route … Read more

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