Introduction Romosozumab is a humanized monoclonal antibody used for the treatment of osteoporosis in postmenopausal women who are at high risk of fracture. It is marketed under the brand name Evenity. Pharmacologically, romosozumab belongs to the sclerostin inhibitor class and is considered an anabolic bone-forming therapy with an additional antiresorptive effect. Osteoporosis is characterized by … Read more
Introduction Abemaciclib is an oral targeted anticancer drug used mainly in hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancer. It is marketed under the brand name Verzenio. Pharmacologically, abemaciclib belongs to the cyclin-dependent kinase 4 and 6 inhibitor class, commonly abbreviated as CDK4/6 inhibitors. CDK4 and CDK6 are important enzymes involved in cell-cycle … Read more
Introduction Valbenazine is an oral drug used for the treatment of abnormal involuntary movements. It is marketed under the brand names Ingrezza and Ingrezza Sprinkle. Pharmacologically, valbenazine is a vesicular monoamine transporter 2 inhibitor, commonly abbreviated as a VMAT2 inhibitor. Valbenazine is mainly used in adults with tardive dyskinesia and chorea associated with Huntington’s disease. … Read more
Introduction Olaparib is an oral anticancer drug that belongs to the poly ADP-ribose polymerase inhibitor class, commonly called PARP inhibitors. It is marketed under the brand name Lynparza. Olaparib is an important targeted anticancer drug used in cancers with defects in DNA repair pathways, especially BRCA1, BRCA2, and other homologous recombination repair gene abnormalities. The … Read more
Introduction Nilotinib is an oral anticancer drug used mainly in Philadelphia chromosome-positive chronic myeloid leukemia, commonly abbreviated as Ph+ CML. It belongs to the BCR-ABL tyrosine kinase inhibitor class. The most widely known brand name is Tasigna, and another formulation is Danziten. Nilotinib is pharmacologically related to imatinib but was designed to bind the BCR-ABL … Read more
Introduction Atogepant is an oral migraine-preventive drug that belongs to the calcitonin gene-related peptide receptor antagonist class. Drugs in this class are commonly called gepants. Atogepant is marketed under the brand name Qulipta in the United States and Aquipta in some other regions. Atogepant is used for the preventive treatment of migraine in adults. It … Read more
Introduction Cladribine is a purine nucleoside analogue used as an immunosuppressive and antineoplastic drug. It is available under important brand names such as Mavenclad for relapsing forms of multiple sclerosis and Leustatin for hairy cell leukemia. Pharmacologically, cladribine is an adenosine analogue that is resistant to degradation by adenosine deaminase, allowing it to persist inside … Read more
Introduction Brilinta is the brand name of ticagrelor, an oral antiplatelet drug used mainly to prevent thrombotic cardiovascular and cerebrovascular events. It belongs to the P2Y12 platelet receptor inhibitor class and is commonly used in patients with acute coronary syndrome, history of myocardial infarction, coronary artery disease at high risk of thrombotic events, and selected … Read more
Introduction Eltrombopag is an oral thrombopoietin receptor agonist used to increase platelet production in selected patients with thrombocytopenia. It is marketed under the brand name Promacta in the United States and Revolade in some other countries. Pharmacologically, eltrombopag is classified as a non-peptide thrombopoietin receptor agonist. Thrombopoietin, also called TPO, is the natural hormone that … Read more
Introduction Lurbinectedin is an intravenous anticancer drug marketed under the brand name Zepzelca. It belongs to the class of alkylating antineoplastic agents and is mainly used in small cell lung cancer, a highly aggressive neuroendocrine lung cancer that often responds initially to platinum-based chemotherapy but commonly relapses. Lurbinectedin is pharmacologically important because it targets DNA … Read more
