Psoriasis Treatment - Pharmacy Freak

Mechanism of Action of Etanercept (Enbrel)

April 10, 2026July 4, 2025 Pharmacy Freak Editorial Team Harsh Singh Rajput

Introduction Etanercept is a biologic fusion protein that functions as a soluble tumor necrosis factor (TNF) receptor. By binding TNF-α and TNF-β in circulation, it blocks their interaction with cell surface receptors, reducing systemic inflammation. It is approved for rheumatoid arthritis (RA), psoriatic arthritis (PsA), ankylosing spondylitis (AS), juvenile idiopathic arthritis (JIA), and plaque psoriasis. … Read more

Mechanism of Action of Apremilast (Otezla)

April 10, 2026July 3, 2025 Pharmacy Freak Editorial Team Harsh Singh Rajput

Introduction Apremilast (Otezla) is an oral phosphodiesterase-4 (PDE4) inhibitor approved for psoriasis, psoriatic arthritis, and Behçet’s disease‑associated oral ulcers. By modulating intracellular signaling, it reduces inflammation and disease symptoms through balanced cytokine regulation. Step-by-Step Mechanism of Action Pharmacokinetic Parameters Parameter Value Route Oral (delayed-release tablet) Bioavailability ~73% Time to Peak (Tmax) ~2–4 hours Protein Binding … Read more