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Pharmacy Freak

Harsh Singh Rajput

Harsh Singh Rajput is a pharmacist currently working at ESIC and holds an MBA in Pharmaceutical Management from NIPER Hyderabad. He has a strong academic record with top ranks in national-level pharmacy exams, including AIR 61 in NIPER 2024 (MS/M.Pharm), AIR 27 in NIPER MBA, AIR 147 in GPAT 2024, AIR 907 in GPAT 2023, and AIR 6 in AIIMS CRE-2025 for Drug Store Keeper. At PharmacyFreak.com, he contributes expert content, exam strategies, and practical guidance for future pharmacists. Mail- harsh@pharmacyfreak.com

Mechanism of Action of Tricyclic Antidepressants (TCAs)

Mechanism of Action of Tricyclic Antidepressants

Introduction Tricyclic antidepressants (TCAs) are a class of antidepressant drugs used in major depressive disorder, neuropathic pain, migraine prophylaxis, obsessive-compulsive disorder, and certain anxiety disorders. Common TCAs include amitriptyline, nortriptyline, imipramine, desipramine, and clomipramine. Their primary action is inhibition of serotonin and norepinephrine reuptake, leading to increased concentrations of these neurotransmitters in the central nervous … Read more

Mechanism of Action of Tadalafil

MOA of Tadalafil

Introduction Tadalafil is a phosphodiesterase type 5 (PDE5) inhibitor used primarily for erectile dysfunction (ED), benign prostatic hyperplasia (BPH), and pulmonary arterial hypertension (PAH). It enhances the effects of nitric oxide-mediated vasodilation by preventing degradation of cyclic guanosine monophosphate (cGMP). Tadalafil is distinguished from other PDE5 inhibitors by its long duration of action, earning it … Read more

Mechanism of Action of Tacrolimus

MOA of Tacrolimus

Introduction Tacrolimus is a potent immunosuppressive agent widely used in organ transplantation and autoimmune diseases. It belongs to the calcineurin inhibitor class and suppresses T-lymphocyte activation by inhibiting interleukin-2 (IL-2) production. Tacrolimus is more potent than cyclosporine and plays a crucial role in preventing graft rejection after organ transplantation. Mechanism of Action (Step-wise) A key … Read more

Mechanism of Action of Sulfonylureas

MOA of Sulfonylureas

Introduction Sulfonylureas are oral antidiabetic drugs used primarily in the treatment of type 2 diabetes mellitus. They lower blood glucose levels by stimulating insulin secretion from pancreatic β-cells. Common sulfonylureas include glibenclamide (glyburide), glipizide, gliclazide, and glimepiride. These drugs are effective only when functional pancreatic β-cells are present. Mechanism of Action (Step-wise) A key exam … Read more

Mechanism of Action of Sulfasalazine

MOA of Sulfasalazine

Introduction Sulfasalazine is a disease-modifying antirheumatic drug (DMARD) and anti-inflammatory agent used primarily in inflammatory bowel disease (IBD), rheumatoid arthritis, and other autoimmune disorders. It is a prodrug consisting of sulfapyridine linked to 5-aminosalicylic acid (5-ASA, mesalamine) by an azo bond. After reaching the colon, bacterial enzymes cleave the bond, releasing the active components that … Read more

Mechanism of Action of Steroids

Mechanism of action of Steroids

Introduction Steroids, specifically corticosteroids such as prednisone, prednisolone, dexamethasone, hydrocortisone, and methylprednisolone, are potent anti-inflammatory and immunosuppressive agents. They mimic the actions of endogenous cortisol and regulate the expression of numerous genes involved in inflammation, immunity, metabolism, and stress responses. Corticosteroids are widely used in autoimmune diseases, allergic disorders, inflammatory conditions, organ transplantation, and many … Read more

Free NIPER Mock Tests | Full Length & Section Wise Tests

Free NIPER JEE Practice Tests Free NIPER Mock Tests | Full Length & Section Wise Tests Practice for NIPER JEE with full length mock tests, section-wise tests and subject-wise tests designed around the latest Master’s entrance pattern. Start with free tests, review your performance and continue with more NIPER-style practice. Start Full Length Tests Section … Read more

Get More Full Length NIPER JEE Mock Test

Continue After 2 Free NIPER Mock Tests Unlock More Full Length NIPER Mock Tests Already practiced the free full length tests? Continue your NIPER JEE preparation with premium ad-free mock tests built for real exam practice, score analysis, answer review and PDF-based revision. 200 MCQs Full length exam format 150 Min Real timer practice +0.5 … Read more

NIPER Biotechnology Microbiology and Immunology Mock Test

Pharmacy Freak · NIPER Biotechnology Microbiology and Immunology Subject-wise Mock Test NIPER Biotechnology Microbiology and Immunology Mock Test Practice Biotechnology, Microbiology and Immunology for NIPER JEE with 40 single-best-answer MCQs in 30 minutes. Full marks: 20. Marking: +0.5 correct / -0.125 incorrect. Unanswered questions carry 0 marks. Auto-submits at 00:00. Questions 40 Max Marks 20 … Read more

NIPER Pharmacognosy and Natural Products Mock Test

Pharmacy Freak · NIPER Pharmacognosy and Natural Products Subject-wise Mock Test NIPER Pharmacognosy and Natural Products Mock Test Practice Pharmacognosy and Natural Products for NIPER JEE with 40 single-best-answer MCQs in 30 minutes. Full marks: 20. Marking: +0.5 correct / -0.125 incorrect. Unanswered questions carry 0 marks. Auto-submits at 00:00. Questions 40 Max Marks 25 … Read more

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