Mechanism of Action of Thiazide Diuretics
Introduction Thiazide diuretics are commonly used antihypertensive and diuretic agents that increase sodium and water excretion by inhibiting sodium reabsorption in the distal convoluted tubule (DCT) of the nephron. Common thiazide diuretics include hydrochlorothiazide, chlorothiazide, and bendroflumethiazide, while thiazide-like diuretics include chlorthalidone, indapamide, and metolazone. These drugs are widely used in hypertension, edema, heart failure, … Read more