Mechanism of Action of Valproate
Introduction Valproate (valproic acid, sodium valproate, and divalproex sodium) is a broad-spectrum antiepileptic drug used in epilepsy, bipolar disorder, and migraine prophylaxis. It is effective against multiple seizure types because it acts through several mechanisms, including enhancement of GABAergic neurotransmission, blockade of voltage-gated sodium channels, and inhibition of T-type calcium channels. Mechanism of Action (Step-wise) … Read more
