Mechanism of Action of Thiazolidinediones (TZDs)
Introduction Thiazolidinediones (TZDs), also known as glitazones, are oral antidiabetic agents used in the management of type 2 diabetes mellitus. The main drugs in this class are pioglitazone and rosiglitazone. Unlike sulfonylureas, TZDs do not stimulate insulin secretion. Instead, they improve insulin sensitivity in peripheral tissues by activating peroxisome proliferator-activated receptor gamma (PPAR-γ), a nuclear … Read more