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Paracetamol – Mechanism of Action

Paracetamol mechanism of action – central COX inhibition and antipyretic action via hypothalamus

Introduction Paracetamol (also known as Acetaminophen) is one of the most commonly used drugs for fever and mild-to-moderate pain. Unlike NSAIDs, it has minimal anti-inflammatory action and does not cause gastric irritation. It is classified as: Despite its widespread use, its exact mechanism of action has long been debated and is often misunderstood—making it a … Read more

Methotrexate – Mechanism of Action

Flowchart of Methotrexate mechanism of action showing DHFR inhibition and suppression of DNA synthesis in S-phase

Introduction Methotrexate is a cornerstone drug in both anticancer chemotherapy and immunosuppressive therapy. Structurally, it is a folic acid antagonist and functions as an antimetabolite. It is widely used in: Due to its dual role in oncology and immunology, Methotrexate is a high-yield topic in exams like GPAT, NIPER, NEET-PG, NCLEX, and essential for PharmD, … Read more

Aspirin – Mechanism of Action

Stepwise mechanism of action of Aspirin showing COX inhibition and antiplatelet effect

Introduction Aspirin, also known as acetylsalicylic acid, is a widely used Non-Steroidal Anti-Inflammatory Drug (NSAID). It’s primarily known for its analgesic (pain-relieving), antipyretic (fever-reducing), anti-inflammatory, and antiplatelet actions. Belonging to the salicylate class, Aspirin is often prescribed for: Due to its clinical importance and frequent exam presence, understanding its mechanism of action is essential for … Read more

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