ADHD Off-label - Pharmacy Freak

Mechanism of Action of Wellbutrin (Bupropion)

April 10, 2026July 2, 2025 Pharmacy Freak Editorial Team Harsh Singh Rajput

Introduction Wellbutrin (bupropion) is an atypical antidepressant and smoking cessation aid. It primarily works by inhibiting reuptake of norepinephrine and dopamine, without affecting serotonin. Additionally, it acts as a nicotinic receptor antagonist, reducing nicotine cravings. Step-by-Step Mechanism of Action Pharmacokinetic Parameters Parameter Value Route Oral (IR, SR, XL formulations) Bioavailability ~5–20% Time to Peak (Tmax) … Read more

Mechanism of Action of Bupropion

April 10, 2026July 1, 2025 Pharmacy Freak Editorial Team Harsh Singh Rajput

Introduction Bupropion is an atypical antidepressant primarily used to treat major depressive disorder, seasonal affective disorder, and as an aid for smoking cessation. Unlike SSRIs, bupropion exerts its effects via modulation of dopamine and norepinephrine neurotransmission, offering a unique mechanism without significant serotonergic side effects. Step-by-Step Mechanism of Action Pharmacokinetic Parameters Parameter Value Route Oral … Read more