Aldosterone Antagonist - Pharmacy Freak

Mechanism of Action of Eplerenone

April 10, 2026January 14, 2026 Pharmacy Freak Editorial Team Harsh Singh Rajput

Introduction Eplerenone is a selective mineralocorticoid receptor antagonist (MRA) used primarily in cardiovascular disorders such as heart failure and hypertension. It is a steroidal compound structurally related to spironolactone but with greater receptor selectivity, resulting in fewer endocrine adverse effects. From an exam and clinical standpoint, eplerenone is important due to its role in blocking … Read more

Mechanism of Action of Spironolactone

June 30, 2025 Pharmacy Freak Editorial Team Harsh Singh Rajput

Introduction Spironolactone is a potassium-sparing diuretic and aldosterone antagonist used primarily in the treatment of heart failure, hypertension, primary hyperaldosteronism, and conditions involving androgen excess such as polycystic ovary syndrome (PCOS) and hirsutism. It works by blocking the action of aldosterone in the distal nephron, thereby reducing sodium reabsorption and potassium excretion. Its antiandrogenic effects … Read more