Mechanism of Action of Spironolactone
Introduction Spironolactone is a potassium-sparing diuretic and aldosterone antagonist used primarily in the treatment of heart failure, hypertension, primary hyperaldosteronism, and conditions involving androgen excess such as polycystic ovary syndrome (PCOS) and hirsutism. It works by blocking the action of aldosterone in the distal nephron, thereby reducing sodium reabsorption and potassium excretion. Its antiandrogenic effects … Read more