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Mechanism of Action of Orlistat

MOA of Orlistat

Introduction Orlistat is a lipase inhibitor used primarily as an anti-obesity agent. It acts locally within the gastrointestinal tract to reduce the absorption of dietary fats. Unlike centrally acting appetite suppressants, orlistat exerts its effect peripherally without affecting the central nervous system. This makes it a valuable pharmacologic option for long-term weight management in obese … Read more

Mechanism of Action of Mounjaro (Tirzepatide)

Mounjaro Mechanism of Action

Introduction Tirzepatide, marketed as Mounjaro for type 2 diabetes and Zepbound for obesity, is a dual GIP/GLP‑1 receptor agonist. This innovative “twincretin” enhances insulin secretion, suppresses glucagon, delays gastric emptying, and promotes satiety. It offers significant HbA₁c reduction and weight loss advantages over GLP‑1 agonists alone. Step-by-Step Mechanism of Action Pharmacokinetic Parameters Parameter Value Route … Read more

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