Introduction SGLT2 Inhibitors, or sodium-glucose co-transporter 2 inhibitors, are a newer class of oral antidiabetic drugs that reduce blood glucose levels by promoting urinary glucose excretion. Unlike insulin-dependent drugs, they work via the kidneys and help in both glycemic control and weight reduction. Commonly used SGLT2 inhibitors include: These drugs are now also used for … Read more
Introduction Dipeptidyl Peptidase-4 (DPP-4) Inhibitors, commonly referred to as gliptins, are oral antidiabetic drugs that enhance the action of incretin hormones, especially GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic peptide). They help regulate postprandial and fasting blood glucose levels in patients with type 2 diabetes mellitus. Commonly used DPP-4 inhibitors include: These agents are known … Read more
Introduction Thiazolidinediones (TZDs), also known as glitazones, are oral antidiabetic drugs used to improve insulin sensitivity in patients with type 2 diabetes mellitus. Unlike insulin secretagogues, TZDs do not stimulate insulin release—they enhance the body’s response to insulin. Common examples include: They act by binding to PPAR-γ (peroxisome proliferator-activated receptor gamma) and modulating gene transcription, … Read more
Introduction Meglitinides, also known as glinides, are short-acting insulin secretagogues used in the treatment of type 2 diabetes mellitus. They function similarly to sulfonylureas but have a more rapid onset and shorter duration of action, making them ideal for postprandial glucose control. Common meglitinides include: These drugs are especially useful for meal-time glucose spikes and … Read more
Introduction Sulfonylureas are one of the oldest and most widely used classes of oral antidiabetic agents. They are particularly effective in patients with type 2 diabetes mellitus who have residual pancreatic beta-cell function. They exert their effect by stimulating insulin secretion from pancreatic beta cells. Sulfonylureas are typically used in combination with other agents or … Read more
Introduction Potassium-sparing diuretics are a unique subclass of diuretics that help conserve potassium levels while promoting mild diuresis. Unlike other diuretics, they do not cause hypokalemia, making them ideal as adjunct therapy with thiazide or loop diuretics. These drugs are grouped into two types: These drugs are tested frequently in USMLE, NCLEX, GPAT, NAPLEX, and … Read more
Introduction Thiazide diuretics are one of the most commonly prescribed classes of antihypertensive agents, especially in the U.S. They are highly effective in treating mild to moderate hypertension and are also useful in managing edema, calcium kidney stones, and heart failure. Examples include: Thiazides are recommended as first-line therapy for hypertension in JNC-8 and AHA/ACC … Read more
Introduction Beta-blockers are a widely used class of drugs in cardiovascular medicine. They block the effects of catecholamines, particularly norepinephrine and epinephrine, on beta-adrenergic receptors. This results in decreased heart rate, myocardial contractility, and renin release, leading to lower blood pressure and decreased myocardial oxygen demand. Common beta-blockers include: Beta-blockers are used in managing hypertension, … Read more
