Neuropathic Pain - Pharmacy Freak

Mechanism of Action of Amitriptyline

April 10, 2026October 10, 2025 Pharmacy Freak Editorial Team Harsh Singh Rajput

Introduction Amitriptyline is a tricyclic antidepressant (TCA) primarily used in the management of major depressive disorder, neuropathic pain, migraine prophylaxis, and insomnia. Mechanism of Action of Amitriptyline involves inhibition of serotonin (5-HT) and norepinephrine (NE) reuptake at presynaptic nerve terminals, thereby increasing their synaptic concentrations. Additionally, it exhibits significant anticholinergic, antihistaminic, and alpha-adrenergic blocking effects, … Read more

Mechanism of Action of Pregabalin (Lyrica)

April 10, 2026September 18, 2025 Pharmacy Freak Editorial Team Harsh Singh Rajput

Introduction Pregabalin, marketed under the brand name Lyrica, is a centrally acting agent approved for neuropathic pain, epilepsy, and generalized anxiety disorder. Although structurally similar to gamma-aminobutyric acid (GABA), pregabalin does not bind to GABA receptors. Instead, it exerts its effects by modulating calcium channels in the central nervous system, leading to decreased neurotransmitter release … Read more

Mechanism of Action of Gabapentin

June 29, 2025 Pharmacy Freak Editorial Team Harsh Singh Rajput

Illustration of Gabapentin's mechanism of action on voltage-gated calcium channels

Introduction Gabapentin is an anticonvulsant and analgesic drug primarily used in the treatment of epilepsy, neuropathic pain, and restless legs syndrome. Though structurally related to gamma-aminobutyric acid (GABA), gabapentin does not bind to GABA receptors or influence GABA metabolism. Instead, it modulates neuronal excitability by interacting with voltage-gated calcium channels. Its favorable safety profile and … Read more