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Mechanism of Action of Gabapentin

Illustration of Gabapentin's mechanism of action on voltage-gated calcium channels

Introduction Gabapentin is an anticonvulsant and analgesic drug primarily used in the treatment of epilepsy, neuropathic pain, and restless legs syndrome. Though structurally related to gamma-aminobutyric acid (GABA), gabapentin does not bind to GABA receptors or influence GABA metabolism. Instead, it modulates neuronal excitability by interacting with voltage-gated calcium channels. Its favorable safety profile and … Read more

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