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Mechanism of Action of Pregabalin (Lyrica)

MOA of Pregabalin

Introduction Pregabalin, marketed under the brand name Lyrica, is a centrally acting agent approved for neuropathic pain, epilepsy, and generalized anxiety disorder. Although structurally similar to gamma-aminobutyric acid (GABA), pregabalin does not bind to GABA receptors. Instead, it exerts its effects by modulating calcium channels in the central nervous system, leading to decreased neurotransmitter release … Read more

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