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Mechanism of Action of Benztropine

MOA of Benztropine

Introduction Benztropine is an anticholinergic and antihistaminic medication commonly used in the treatment of Parkinson’s disease and drug-induced extrapyramidal symptoms (EPS) such as dystonia, akathisia, and parkinsonism caused by antipsychotics. Its therapeutic effect comes from restoring the dopamine–acetylcholine balance in the basal ganglia. Benztropine blocks muscarinic receptors, reducing cholinergic activity, and provides antihistaminic sedation that … Read more

Mechanism of Action of Amantadine

Mechanism of action of Amantadine

Introduction Amantadine is an antiviral agent and antiparkinsonian medication. Initially used for influenza A, it also treats drug-induced extrapyramidal symptoms and Parkinson’s disease. Its mechanism combines viral M2 ion channel inhibition and enhancement of dopaminergic neurotransmission in the central nervous system. Step-by-Step Mechanism of Action Pharmacokinetic Parameters Parameter Value Route Oral (capsule, syrup) Bioavailability ~86% … Read more

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