Aspirin - Pharmacy Freak

Mechanism of Action of Aspirin as an Antiplatelet Drug

April 10, 2026November 11, 2025 Pharmacy Freak Editorial Team Harsh Singh Rajput

Introduction Aspirin (Acetylsalicylic Acid, ASA) is the most widely used antiplatelet agent in clinical medicine. Its antiplatelet mechanism of action is distinct because it causes irreversible inhibition of platelet cyclooxygenase-1 (COX-1), blocking the formation of thromboxane A₂ (TXA₂) — a potent inducer of platelet aggregation and vasoconstriction. Low-dose aspirin (typically 75–150 mg/day) preferentially inhibits platelet … Read more

Mechanism of Action of Antiplatelet Drugs

April 10, 2026November 10, 2025 Pharmacy Freak Editorial Team Harsh Singh Rajput

Introduction Antiplatelet drugs are pharmacological agents that inhibit platelet aggregation, thereby preventing arterial thrombosis — a key contributor to myocardial infarction, ischemic stroke, and peripheral artery disease. Mechanism of Action of Antiplatelet Drugs involves blocking platelet activation pathways mediated by cyclooxygenase (COX-1), ADP receptors (P2Y₁₂), glycoprotein IIb/IIIa receptors, and thromboxane A₂ synthesis. Unlike anticoagulants, which … Read more

Aspirin Chemical Structure

October 13, 2025 Harsh Singh Rajput

Aspirin (acetylsalicylic acid) 2D chemical structure, C9H8O4, salicylate ester

1. Identification SummaryAspirin (acetylsalicylic acid) is a nonsteroidal anti-inflammatory drug (NSAID) used for analgesia, antipyresis, anti-inflammation, and—at low doses—irreversible antiplatelet therapy for cardiovascular prevention. Brand NamesAspirin, Ecotrin, Aspro, Disprin, Bayer Aspirin (regional variants and generics) NameAspirin (Acetylsalicylic acid) BackgroundA salicylate ester developed in the late 19th century; its acetylation of platelet COX-1 underlies long-lasting antiplatelet … Read more