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Mechanism of Action of Haloperidol

Mechanism of Action of Haloperidol

Introduction Haloperidol is a first generation (typical) antipsychotic belonging to the butyrophenone class. It is widely used in the treatment of schizophrenia, acute psychosis, delirium, and severe agitation. Haloperidol primarily works by blocking dopamine receptors in the central nervous system, particularly in the mesolimbic pathway. Because excessive dopamine activity in the mesolimbic pathway is associated … Read more

Mechanism of Action of Chlorpromazine

Chlorpromazine D2 receptor blockade

Introduction Chlorpromazine is a first-generation (typical) antipsychotic, belonging to the phenothiazine class. It is used for schizophrenia, acute psychosis, bipolar mania, severe agitation, intractable hiccups, nausea, and tetanus-associated agitation. The Mechanism of Action of Chlorpromazine centers on dopamine D2 receptor antagonism in the mesolimbic system, along with additional blockade of histamine, muscarinic, and alpha-1 adrenergic … Read more

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