T2DM Treatment - Pharmacy Freak

Mechanism of Action of Januvia (Sitagliptin)

April 10, 2026July 2, 2025 Pharmacy Freak Editorial Team Harsh Singh Rajput

Introduction Januvia (sitagliptin) is an oral dipeptidyl peptidase‑4 (DPP‑4) inhibitor used to improve glycemic control in type 2 diabetes mellitus (T2DM). It enhances incretin levels, thereby increasing insulin secretion and lowering glucagon in a glucose-dependent manner. Step-by-Step Mechanism of Action Pharmacokinetic Parameters Parameter Value Route Oral (tablet) Bioavailability ~87% Time to Peak (Tmax) ~1–4 hours Protein … Read more

Mechanism of Action of Farxiga (Dapagliflozin)

April 10, 2026July 1, 2025 Pharmacy Freak Editorial Team Harsh Singh Rajput

Introduction Dapagliflozin (trade name Farxiga) is a sodium–glucose co‑transporter 2 (SGLT2) inhibitor used in type 2 diabetes mellitus (T2DM) and heart failure with reduced ejection fraction (HFrEF). It lowers blood glucose by promoting renal excretion of glucose and also provides cardiovascular and renal benefits beyond glycemic control. Step-by-Step Mechanism of Action Pharmacokinetic Parameters Parameter Value Route Oral … Read more