Mechanism of Action of Januvia (Sitagliptin)
Introduction Januvia (sitagliptin) is an oral dipeptidyl peptidase‑4 (DPP‑4) inhibitor used to improve glycemic control in type 2 diabetes mellitus (T2DM). It enhances incretin levels, thereby increasing insulin secretion and lowering glucagon in a glucose-dependent manner. Step-by-Step Mechanism of Action Pharmacokinetic Parameters Parameter Value Route Oral (tablet) Bioavailability ~87% Time to Peak (Tmax) ~1–4 hours Protein … Read more