Mechanism of Action of Tysabri

Introduction Tysabri is the brand name of natalizumab, a biologic immunomodulator used mainly in multiple sclerosis and Crohn’s disease. Pharmacologically, natalizumab is a recombinant humanized IgG4 monoclonal antibody that targets alpha-4 integrin. Alpha-4 integrins are adhesion molecules found on the surface of many leukocytes. These molecules help immune cells attach to blood vessel walls and … Read more